The Hunt for Baby Melanomas: A Prospective Study of the Dermoscopy Features on 100 Small Melanoma Cases with Vivo Surface Diameters up to a Maximum of 6 mm.

Introduction: Early diagnosis can improve melanoma prognosis. Dermoscopy can enhance early melanoma recognition.

Objectives: Examine the dermoscopy features of early melanoma up to a maximum surface diameter of 6 mm.

Do prophylactic steroids prevent chemical meningitis in surgery for epidermoid cysts? Case report and literature review.

Background: Cranial and spinal epidermoid cysts (ECs) are rare and surgical resection can be complicated by chemical meningitis. Here, we treated a patient undergoing surgical resection of an intramedullary spinal EC with prophylactic steroids to help prevent postoperative chemical meningitis. Notably, we found a paucity of evidence regarding the efficacy of steroids used for this purpose.

Basal cell carcinoma with perineural invasion: A prospective study examining subtype, tumor surface diameter, invasion depth, and anatomic site in 3005 consecutive cases.

Background: Basal cell carcinoma (BCC) may present with or without perineural invasion (PNI). We reviewed BCC for PNI by subtype, microscopic tumor surface diameter, invasion depth, and anatomic site.

Method: Consecutive excisions were prospectively collected in an Australian center 2016-2018.

Early Squamous Cell Carcinoma With Perineural Invasion: A Prospective Study Examining Anatomic Site, Tumor Surface Diameter, Invasion Depth, and Grade of Differentiation in 1,772 Consecutive Cases.

Background: Squamous cell carcinoma (SCC) may present with perineural invasion (PNI).

Objective: To investigate the characteristics of early invasive SCC with or without PNI.

Methods: Consecutive SCC excisions were prospectively reviewed from a single Australian community-based practice for 2016-2018.

Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant.

Squamous Cell Carcinoma (SCC) with Osteoclast-like giant cell (OLGC) is a rare SCC variant; only 10 cases have been reported. Our case suggests OLGC are resultant of a reactive process, driven by the fusion of adjacent macrophages. Knowledge regarding SCC with OLGC is of great importance as this entity has greater prometastatic potential compared to conventional SCC.

Basal cell carcinoma: variation in invasion depth by subtype, sex, and anatomic site in 4,565 cases.

Background: The depth of invasion by basal cell carcinoma (BCC) subtypes varies.

Objective: To investigate BCC invasion depth variation by subtype and anatomic site.

Method: A prospective consecutive case series of excised BCC from 2009 to 2014 in a single Australian clinic.

Early invasive squamous cell carcinoma recurrence rates: A study examining surgical margins, tumor surface diameter, invasion depth, and grade of differentiation in 1296 cases over 9 years.

Background: Invasive squamous cell carcinoma (SCC) is typically treated by surgical excision.

Methods: Consecutive SCC excisions were reviewed prospectively in a single Australian center from 2009 to 2017. Cases were examined for recurrence by histopathologic margins, microscopic tumor surface diameter, invasion depth, grade of differentiation, and anatomic site.

Superficial basal cell carcinoma: A comparison of superficial only subtype with superficial combined with other subtypes by age, sex and anatomic site in 3150 cases.

Background: Basal cell carcinoma (BCC) may present as superficial subtype alone (sBCC) or superficial combined with other subtypes. The objective of this study was to compare sBCC without or with other BCC subtypes by age, sex and anatomic site.

Methods: We retrospectively collected superficial BCC with the above characteristics from an Australian center during 2009 to 2014.

Invasive Squamous Cell Carcinoma: A Comparison of Tumors With or Without Horn Presentation Based on Age, Sex, Anatomic Site, Tumor Diameter, Depth of Invasion, and Grade of Differentiation in 1,666 Cases.

Introduction: Invasive squamous cell carcinoma (SCC) may present clinically with or without a horn.

Objective: To compare invasive SCC with or without horn presentation by anatomic site, tumor diameter, depth, and grade of differentiation.

Materials And Methods: The above characteristics of invasive SCC with or without horns were compared using a logistic regression model adjusted for potential confounders.

Changes in Epithelium, Stroma, and Lumen Space Correlate More Strongly with Gleason Pattern and Are Stronger Predictors of Prostate ADC Changes than Cellularity Metrics.

Purpose: To investigate the hypothesis that the clinically observed decrease in apparent diffusion coefficient (ADC) at diffusion-weighted magnetic resonance imaging with increasing prostate cancer Gleason grade can be attributed to an increasing volume of low-diffusivity epithelial cells and corresponding decreasing volumes of higher-diffusivity stroma and lumen space rather than to increased cell density.

Materials And Methods: Tissue samples were acquired after institutional ethics review committee approval and informed consent from patients were obtained. Nuclear count, nuclear area, and gland component volumes (epithelium, stroma, lumen space) were measured in tissue from 14 patients.

Fulminant Clostridium Septicum myonecrosis in well controlled diabetes: a case report.

Diabetic myonecrosis with Clostridium Septicum is uncommon but carries a high mortality rate. This commensal organism is part of the gastrointestinal tract flora and can become extremely virulent, often in the setting of immuno-suppression such as neutropenia, occult malignancy (commonly caecal) and poorly controlled diabetes. The case report is unusual in that there are few risk factors other than very mild neutropenia.