Neonatal ascites in autosomal recessive polycystic kidney disease (ARPKD).

Background: Neonatal ascites is a rare entity, which is usually biliary, urinary, or chylous. Congenital hepatic fibrosis as part of the manifestations of autosomal recessive polycystic kidney disease (ARPKD) is usually a histological adjunct to the diagnosis of this mainly clinically renal entity in the neonatal period. Case-diagnosis: We describe a rare case of severe ascites in a newborn child complicating ARPKD, which was later confirmed by clinical, histological, and genetic studies.

Colchicine-sensitive nephrotic syndrome due to AA amyloidosis.

A 28-year-old women is presented who was evaluated for a new-onset postpartum nephrotic syndrome with normal renal function. Histological diagnosis was AA amyloidosis but no underlying disease has been diagnosed despite extensive workup. Complete remission was achieved with colchicine.

Positive placental staining for alkaline phosphatase corresponding with extreme elevation of serum alkaline phosphatase during pregnancy.

Placental ALP (ALP(h)) is a membrane-anchored, heat-stable enzyme produced by the syncytiotrophoblast. We report a case of a patient presenting in the third trimester with extreme increased levels of ALP(h). A 40-year-old woman, gravida 2, para 1, was admitted to the high risk pregnancy unit at 30 weeks of gestation for evaluation of an incidental finding of marked isolated elevation in serum ALP(h).

Isolated congenital histiocytosis in the palpebral conjunctiva in a newborn.

Purpose: To report a rare case of congenital histiocytosis in a newborn without skin involvement.

Design: Interventional case-report.

Methods: A full-term baby presented with a mass over the palpebral conjunctiva of his left upper lid.

Ophthalmic manifestations in Langerhans cell histiocytosis.

Histiocytosis of childhood is characterized by localized or generalized proliferation of cells of the mononuclear phagocyte system and the dendritic cell system. In patients with Langerhans cell histiocytosis, the orbit is the most involved site encountered in ophthalmic practice, usually as a lytic lesion in the zygomaticofrontal suture. Patients usually present with acute or chronic periorbital swelling.

Langerhans cell histiocytosis with periorbital cellulitis.

Purpose: To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis.

Design: Interventional case report.

Methods: A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration.