Effect of antithrombotic stewardship on the efficacy and safety of antithrombotic therapy during and after hospitalization.

Background: Although the benefits of antithrombotic drugs are indisputable to reduce thrombotic events, they carry a high risk of compromising patient safety. No previous studies investigated the implementation and (cost-) effectiveness of a hospital-based multidisciplinary antithrombotic team on bleeding and thrombotic outcomes. The primary aim of this study was to compare the proportion of patients with a composite end point consisting of one or more bleeding episodes or one or more thrombotic event from hospitalization until three months after hospitalization.

Risk of bleeding in hospitalized patients on anticoagulant therapy: Prevalence and potential risk factors.

Introduction: Bleeding is the most important complication of treatment with anticoagulant therapy. Although several studies have identified risk factors of bleeding in outpatients, no studies have been performed that evaluated prevalence and potential risk factors of bleeding in hospitalized patients treated with anticoagulant therapy.

Methods: The primary objective of this study was to determine the prevalence of bleeding in anticoagulant users during hospitalization.