Publications by authors named "Esther Henriet"
Article Synopsis
- Progress has been made in managing inflammation in multiple sclerosis, but effective repair of demyelinated lesions remains a challenge, as many remyelination candidates have failed in clinical trials.
- A new transgenic model using Xenopus laevis allows for the assessment of spontaneous remyelination and its correlation with functional recovery, which is measured through swimming speed and behavior in response to virtual collisions.
- The study shows that successful remyelination, indicated by histological assessment, aligns with improved functional outcomes, suggesting that combining histopathological and functional evaluations could enhance the screening of potential remyelination therapies.
Background: In multiple sclerosis, development of screening tools for remyelination-promoting molecules is timely.
Objective: A Xenopus transgenic line allowing conditional ablation of myelinating oligodendrocytes has been adapted for in vivo screening of remyelination-favoring molecules.
Methods: In this transgenic, the green fluorescent protein reporter is fused to E.