Parametric Methods for Dynamic C-Phenytoin PET Studies.

In this study, the performance of various methods for generating quantitative parametric images of dynamic C-phenytoin PET studies was evaluated. Double-baseline 60-min dynamic C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method, and spectral analysis.

Quantification of Dynamic 11C-Phenytoin PET Studies.

Unlabelled: The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, (11)C-phenytoin has been evaluated preclinically as a tracer for Pgp. The aim of the present study was to assess the optimal plasma kinetic model for quantification of (11)C-phenytoin studies in humans.