Helping children cope with a mother's breast cancer diagnosis: 'The telling box' - A pilot study.

Objective: Discussing cancer with children presents challenges. Evidence underscores the importance of transparent communication in aiding children's coping mechanisms amidst a parent's diagnosis. 'The telling box' intervention was developed to assist mothers in discussing cancer with their children.

Selecting interventions for a psychosocial support program for prostate cancer patients undergoing active surveillance: A modified Delphi study.

Objective: Curative treatment of low-risk prostate cancer (LR-PCa) does not improve cancer specific survival and active surveillance (AS) is recommended. Although AS is cost-effective and reduces treatment-related complications, it requires psychosocial support. Research on psychosocial interventions specifically focused on men undergoing AS is limited.

What interventions affect the psychosocial burden experienced by prostate cancer patients undergoing active surveillance? A scoping review.

Purpose: Living with untreated prostate cancer (PCa) may cause anxiety and uncertainty in men undergoing active surveillance (AS). Developing a psychosocial support program for such patients might promote psychosocial well-being and patient engagement. This review aims to identify interventions with the potential to influence the psychosocial burden of prostate cancer patients undergoing AS.

Socioeconomic Status and Health-Compromising Behaviour: Is it All About Perception?

Socioeconomic status (SES) is associated with many health issues and health-compromising behaviour (HCB). Most research is based on objective indicators of SES, even though subjective SES, someone's perception of their social standing, is also related to health. Moreover, perceptions of health and HCB might also be of importance.

Crossroad decisions in deep endometriosis treatment options: a qualitative study among patients.

Objective: To study the experiences, considerations, and motivations of patients with endometriosis in the decision-making process for deep endometriosis (DE) treatment options.

Design: Qualitative study using semi-structured in-depth focus group methodology.

Setting: University medical center.

[What makes residents of care centers feel at home and satisfied: a Delphi study].

A major event in the human life course is the move to a care center. In order for this transition to be successful, it is important that a care center creates the right conditions to achieve that residents feel at home and satisfied. The aim of this study is to investigate which characteristics are important for this,  according to the employees of care centers in the Netherlands.

"The child is our focus": On couple issues in child oncology treatment.

Objective: This study explored the perspectives of child oncology professionals and parents about the attention professionals should give to the parent couple relationship during treatment of the child.

Methods: We employed a qualitative research design, framed within the approach of consensual qualitative research (CQR), gathering data from four focus groups with 20 professionals and from nine in-depth interviews with 16 parents. Thematic analysis of the focus group and interview data was done with MaxQda software, using two coders and member checks to strengthen confidence in the analysis.

Parametric Methods for Dynamic C-Phenytoin PET Studies.

In this study, the performance of various methods for generating quantitative parametric images of dynamic C-phenytoin PET studies was evaluated. Double-baseline 60-min dynamic C-phenytoin PET studies, including online arterial sampling, were acquired for 6 healthy subjects. Parametric images were generated using Logan plot analysis, a basis function method, and spectral analysis.

Altered GABAA receptor density and unaltered blood-brain barrier [11C]flumazenil transport in drug-resistant epilepsy patients with mesial temporal sclerosis.

Studies in rodents suggest that flumazenil is a P-glycoprotein substrate at the blood-brain barrier. This study aimed to assess whether [C]flumazenil is a P-glycoprotein substrate in humans and to what extent increased P-glycoprotein function in epilepsy may confound interpretation of clinical [C]flumazenil studies used to assess gamma-aminobutyric acid A receptors. Nine drug-resistant patients with epilepsy and mesial temporal sclerosis were scanned twice using [C]flumazenil before and after partial P-glycoprotein blockade with tariquidar.

The influence of social support on patients' quality of life after an intensive care unit discharge: A cross-sectional survey.

Objectives: To determine the influence of instrumental, emotional and informative support on the quality of life of former intensive care unit (ICU) patients and to establish their preferred sources of social support.

Research Methodology: In a cross-sectional survey, former intensive care patients (n=88) completed the "social support interactions/discrepancies list", the "RAND-36 Health Survey" and reported their preferred sources of the different types of social support.

Setting: A 35 bed intensive care unit in the Radboudumc university hospital in the Netherlands.

Quantification of 11C-Laniquidar Kinetics in the Brain.

Unlabelled: Overexpression of the multidrug efflux transport P-glycoprotein may play an important role in pharmacoresistance. (11)C-laniquidar is a newly developed tracer of P-glycoprotein expression. The aim of this study was to develop a pharmacokinetic model for quantification of (11)C-laniquidar uptake and to assess its test-retest variability.

Quantification of Dynamic 11C-Phenytoin PET Studies.

Unlabelled: The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, (11)C-phenytoin has been evaluated preclinically as a tracer for Pgp. The aim of the present study was to assess the optimal plasma kinetic model for quantification of (11)C-phenytoin studies in humans.

The dopamine stabilizer (-)-OSU6162 occupies a subpopulation of striatal dopamine D2/D3 receptors: an [(11)C]raclopride PET study in healthy human subjects.

(-)-OSU6162 is a dopamine stabilizer that can counteract both hyperdopaminergic and hypodopaminergic states. In this study, D2/D3 receptor occupancy of (-)-OSU6162 in the human brain was investigated using positron emission tomography (PET). Twelve male healthy volunteers underwent [(11)C]raclopride PET scanning before and 1 h after a single oral dose of (-)-OSU6162 (15-90 mg).

Intention to abstain from smoking among cardiac rehabilitation patients: the role of attitude, self-efficacy, and craving.

Background: Smoking cessation after developing coronary heart disease improves disease prognosis more than any other treatment. However, many cardiac patients continue to smoke after hospital discharge.

Objective: The aim of this study was to investigate factors associated with the intention to (permanently) abstain from smoking among cardiac rehabilitation patients 2 to 4 weeks after discharge from hospital.

Relatives' perspectives on the quality of care in an Intensive Care Unit: the theoretical concept of a new tool.

Objective: To examine the potential of a questionnaire (CQI 'R-ICU') to measure the quality of care from the perspective of relatives in the Intensive Care Unit (ICU).

Methods: A quantitative survey study has been undertaken to explore the psychometric properties of the instrument, which was sent to 282 relatives of ICU patients from the Erasmus MC, an academic hospital in Rotterdam, the Netherlands. Factor-analyses were performed to explore the underlying theoretical structure.

Psychological determinants of pregnancy-related lumbopelvic pain: a prospective cohort study.

Objective: To study whether pregnancy-related lumbopelvic pain outcomes at 36 weeks of gestation can be predicted by psychological determinants earlier in pregnancy.

Design: Prospective cohort study.

Setting: Nine midwifery practices in different regions of the Netherlands.

Reliability and validity of a qualitative and quantitative motor test for 5- to 6-year-old children.

Clumsiness in preschool children may be a precursor to impaired academic performance and psychological and developmental problems. It is assumed that in this age group especially the qualitative aspects (=pattern) of a movement reflect variations in motor development. Currently available motor tests for this age group, however, mostly objectify quantitative aspects of a movement alone and do not objectify qualitative aspects.