Clinical predictive models for recurrence and survival in treated laryngeal and hypopharyngeal cancer: a systematic review and meta-analysis.

Background: The limitations of the traditional TNM system have spurred interest in multivariable models for personalized prognostication in laryngeal and hypopharyngeal cancers (LSCC/HPSCC). However, the performance of these models depends on the quality of data and modelling methodology, affecting their potential for clinical adoption. This systematic review and meta-analysis (SR-MA) evaluated clinical predictive models (CPMs) for recurrence and survival in treated LSCC/HPSCC.

Systematic review of prognostic models for predicting recurrence and survival in patients with treated oropharyngeal cancer.

Objectives: This systematic review aims to evaluate externally validated models for individualised prediction of recurrence or survival in adults treated with curative intent for oropharyngeal cancer.

Design: Systematic review.

Setting: Hospital care.

Vaccinating healthcare workers against influenza to protect the vulnerable--is it a good use of healthcare resources? A systematic review of the evidence and an economic evaluation.

Influenza causes substantial mortality in high-risk groups despite targeted vaccination programmes. This paper considers whether it is worth vaccinating healthcare workers (HCWs) against influenza to protect high-risk patients in a series of systematic reviews and an economic evaluation. Eighteen studies are included.

Universal vaccination of children against influenza: are there indirect benefits to the community? A systematic review of the evidence.

We present a systematic review of the effectiveness of vaccinating healthy children to protect others. Primary studies were identified by searching standard electronic databases, internet sites, trials registers and citation lists to January 2004 and subjected to critical appraisal. Eight randomised controlled trials, three community studies and three economic evaluations met the inclusion criteria.