Publications by Esther A Seeds

Publications by authors named "Esther A Seeds"

Page 1 of 1

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diisopropylphenoxy)-9,10-dimethoxy-4H-pyrimido[6,1-a]isoquinolin-4-one].

Victoria Boswell-Smith Domenico Spina Alec W Oxford Mike B Comer Esther A Seeds

J Pharmacol Exp Ther

August 2006

Article Synopsis

- The study investigates the pharmacological effects of two novel PDE3/4 inhibitors, RPL554 and RPL565, which demonstrate significant inhibition of contractions in guinea pig tracheal preparations, indicating potential for respiratory applications.
- Both compounds effectively suppress the release of inflammatory markers from human monocytes and reduce cell proliferation, showcasing their anti-inflammatory properties in various in vitro assays.
- In vivo tests reveal that RPL554 and RPL565 substantially inhibit eosinophil recruitment and inflammation responses in guinea pigs, suggesting their promise as long-acting treatments for respiratory conditions.

View Article and Find Full Text PDF

Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294.

Donna D Gale Peter Hofer Domenico Spina Esther A Seeds Katherine H Banner

Pulm Pharmacol Ther

July 2003

V11294 is a new cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor of the rolipram class. In this report we present the pharmacological profile of V11294. V11294 inhibited PDE4 isolated from human lung with IC(50) 405 nM, compared to 3700 nM for rolipram.

View Article and Find Full Text PDF