Changes in risk behavior and dynamics of hepatitis C virus infections among young drug users in Amsterdam, the Netherlands.

To elucidate the character and magnitude of the hepatitis C virus (HCV) epidemic among drug users in Amsterdam, 197 young drug users from the period 2000 to 2004 were compared with 215 counterparts from 1985 to 1989. Although injection risk behavior and HCV seroprevalence decreased sharply over time, HCV seroprevalence remains high (44%) among young drug users who have ever injected. Phylogenetic analysis shows that current HCV infections originate from diversification of strains already circulating in the past, but also from the recent introduction of new subtypes.

Amount of self-reported illicit drug use compared to quantitative hair test results in community-recruited young drug users in Amsterdam.

Aims: To assess the dose-effect relationship between self-reported drug intake and the concentration of drugs and/or their metabolites in hair and to examine factors that may mediate this relationship.

Design And Setting: A cohort study among young drug users (YDU) in Amsterdam, the Netherlands, which began in July 2000. At intake, YDU were asked to report their average drug intake over a 2-month period.

HIV prevalence and risk behaviour in young drug users in Amsterdam.

Objectives: To assess the HIV prevalence and risk behaviour among regular young drug users (YDU) in Amsterdam.

Design: Subjects were 282 YDU (using heroin, cocaine, methadone and/or amphetamines at least 3 days/week) aged 30 years or less who participated in a cross-sectional survey in Amsterdam in 1998. Participants were recruited both directly (41%) through healthcare institutions, and indirectly (59%) by referrals from YDU already enrolled.