Publications by authors named "Esteves B"

Although edible insects (EIs) are encouraged as a sustainable source of protein, their consumption is not as generalised as other types of food that are internationally accepted. While in some regions of the world, EIs are part of the gastronomic and cultural traditions, in other regions, people are not so receptive to this type of food, and some people even express some disgust towards it. Hence, this research focused on the habits of the participants regarding the consumption of insects as well as their perceptions about EIs being or not a part of the local culture or gastronomic patrimony.

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Aublet is a floating aquatic plant, capable of absorbing the excess of nutrients and water contaminants and can be used in effluent treatment plants. The ability to survive in degraded areas may be related to the association with beneficial bacteria capable of promoting plant growth. However, little is known about the microbiota associated with this aquatic plant and its potential application to the aquatic environment.

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This paper demonstrates the potential of Raman spectroscopy for differentiating neoplastic from non-neoplastic colon tumors, obtained with the CAM (chicken chorioallantoic membrane) model. For the CAM model two human cell lines were used to generate two types of tumors, the RKO cell line for neoplastic colon tumors and the NCM460 cell line for non-neoplastic colon tumors. The Raman spectra were acquired with a 785 nm excitation laser.

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Polyalcohol liquefaction can be performed by acid or base catalysis, producing polyols with different properties. This study compared the mechanical properties of foams produced using polyols from liquefied obtained by acid and base catalysis and using two different foam catalysts. The differences were monitored using FTIR analysis.

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Hazelnut shells (HS), scientifically known as L. shells, are waste produced by companies that process nuts. The main objective of this study was to find an efficient way to maximize the chemical potential of HS by solubilizing the hemicelluloses, which could then be used to recover sugars and, at the same time, increase the lignin content of this material to produce adhesives or high-strength foams.

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Article Synopsis
  • The SORAYA trial investigated the efficacy of mirvetuximab soravtansine-gynx in patients with FRα-high platinum-resistant ovarian cancer, achieving a primary endpoint with an objective response rate of 32.4%.
  • With a median overall survival of 15.0 months, those with fewer previous therapies had better outcomes (18.7 months for one to two lines vs. 11.6 months for three lines).
  • Response rates varied by treatment history, with a higher objective response rate noted in patients receiving mirvetuximab as their first treatment in the platinum-resistant setting (34.8%) compared to those who had prior therapies (28.2%).
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Animals have been used as models to help to better understand biological and anatomical systems, and pathologies in both humans and non-human species, and sheep are often used as an experimental model for orthopedic research. Gait analysis has been shown to be an important tool in biomechanics research with clinical applications. The purpose of this study was to perform a kinematic analysis using a tridimensional (3D) reconstruction of the sheep hindlimb.

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Because edible insects (EI) have been, in recent years, recommended as a nutritious animal protein food with enormous environmental advantages over other sources of animal protein for human consumption, studies aimed at investigating the consumer perspective have become more prominent. Hence, this study intended to examine the perceptions of participants from different countries about the commercialization and economic and social impacts of edible insects. The study was made using a questionnaire survey, and data were collected in Brazil, Croatia, Greece, Latvia, Lebanon, Lithuania, Mexico, Poland, Portugal, Romania, Serbia, Slovenia, Spain, and Turkey.

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Currently, in the context of biorefinery and bioeconomy, lignocellulosic biomass is increasingly used to produce biofuels, biochemicals and other value-added products. Microwaves and ultrasound are emerging techniques that enable efficient and environmentally sustainable routes in the transformation of lignocellulosic biomass. This review presents some of the most important works published in the last few years on the application of microwaves and/or ultrasound in lignocellulosic materials pretreatment and can be used as a starting point for research into this theme.

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Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause of death worldwide. Within this context, nanotechnology offers specific benefits in terms of cancer therapy by reducing its adverse effects and guiding drugs to selectively target cancer cells. In this comprehensive review, we have summarized the most relevant novel outcomes in the range of 2010-2023, covering the design and application of nanosystems for cancer therapy.

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Article Synopsis
  • Mirvetuximab soravtansine is a newly approved treatment for folate receptor-α positive ovarian cancer, and this study aimed to create a model to track its concentration over time in patients.
  • The study involved 543 patients and utilized a nonlinear mixed-effects modeling approach to analyze how the drug and its metabolites behave in the body after intravenous administration.
  • The findings indicated that the standard dose of 6 mg/kg does not need adjustments based on factors like body weight, age, or mild to moderate organ impairments, making it easier for patient management.
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Prepregs are commonly fabricated with non-renewable petroleum-based materials. To reduce the impact of the manufacturing of these materials and to produce more sustainable prepregs, this research aims to manufacture poly(furfuryl alcohol)/wood veneer prepregs and their posterior molding in laminate composites. For this purpose, the vacuum infusion process was used to impregnate the wood veneers, and compression molding was applied to manufacture three- and four-layer laminate composites.

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It is increasingly assumed that there is no one-size-fits-all approach to dietary recommendations for the management and treatment of chronic diseases such as obesity. This phenomenon that not all individuals respond uniformly to a given treatment has become an area of research interest given the rise of personalized and precision medicine. To conduct, interpret, and disseminate this research rigorously and with scientific accuracy, however, requires an understanding of treatment response heterogeneity.

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Barite (BaSO) precipitation is one of the most ubiquitous examples of secondary sulfate mineral scaling in shale oil and gas reservoirs. Often, a suite of chemical additives is used during fracturing operations to inhibit the accumulation of mineral scales, though their efficacy is widely varied and poorly understood. This study combines experimental data and multi-component numerical reactive transport modeling to offer a more comprehensive understanding of the geochemical behavior of barite accumulation in shale matrices under conditions typical of fracturing operations.

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The first line medication for the treatment of type 2 diabetes is metformin. This study aims to investigate the safety profile of metformin and metformin combination medications in older adults using pharmacovigilance data. A literature search was used to identify published clinical studies reporting safety of metformin in older patients (age ≥ 65 years old), which were then thoroughly evaluated.

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At Portuguese-organized cervical cancer (CC) screening programs, all women testing positive for human papillomavirus (HPV) 16 and/or 18 are referred for immediate colposcopy. This study aimed to evaluate the utility of reflex cytology in women who test positive for HPV 16 and/or 18 to improve the efficiency of CC screening. A cross-sectional and retrospective study was performed based on data from the routine CC screening protocol in force at Cova da Beira University Hospital Center, Portugal between August 2012 and June 2021.

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In recent years, nanocellulosic materials have attracted special attention because of their performance in different advanced applications, biodegradability, availability, and biocompatibility. Nanocellulosic materials can assume three distinct morphologies, including cellulose nanocrystals (CNC), cellulose nanofibers (CNF), and bacterial cellulose (BC). This review consists of two main parts related to obtaining and applying nanocelluloses in advanced materials.

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Paulownia wood has raised high attention due to its rapid growth and fire resistance. The number of plantations in Portugal has been growing, and new exploitation methods are needed. This study intends to determine the properties of particleboards made with very young Paulownia trees from Portuguese plantations.

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Reformulating packaged foods has the potential to improve the nutrient density of the global diet. The present perspective illustrates The Kraft Heinz Company's approach to product (re)formulation to develop healthier product lines that are lower in saturated fats, total sugars, and sodium, and contain health promoting components. Here we present the rationale for The Kraft Heinz Company's global nutrition targets used for the global innovation and renovation of foods and beverages.

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Article Synopsis
  • Mirvetuximab soravtansine (MIRV) is a new treatment targeting folate receptor α (FRα) for patients with platinum-resistant epithelial ovarian cancer (PROC), evaluated in the SORAYA study.
  • The study involved 106 patients, primarily with advanced treatment histories, finding an objective response rate (ORR) of 32.4% with a median response duration of 6.9 months.
  • While MIRV showed promising efficacy, common side effects included blurred vision, keratopathy, and nausea, which sometimes led to treatment modifications for nearly half of the patients.
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Polyimide is an emerging and very interesting material for substrate and passivation of neural probes. However, the standard curing temperature of polyimide (350 °C) is critical for the microelectrodes and contact pads of the neural probe, due to the thermal oxidation of the metals during the passivation process of the neural probe. Here, the fabrication process of a flexible neural probe, enhanced with a photosensitive and low-temperature cured polyimide, is presented.

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Objective: To perform a systematic review and meta-analysis of randomized clinical trials that compared the use of antibiotics versus placebo in premature rupture of membranes preterm and evaluated maternal, fetal and neonatal outcomes in pregnant women with premature rupture of ovular membranes at a gestational age between 24 and 37 weeks.

Methods: A search was conducted using keywords in PubMed, Cochrane, Biblioteca Virtual em Saúde and Biblioteca Digital de Teses e Dissertações da USP between August 2018 and December 2021. A total of 926 articles were found.

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Article Synopsis
  • The Omicron-BA.1 variant of concern became the dominant strain globally in early 2022, prompting the need for extensive research using primary cell cultures and animal models to understand its characteristics compared to the Delta variant.* -
  • In laboratory studies, Omicron-BA.1 showed increased early replication in human nasal cells but less replication in bronchial cells; however, in animal models like hamsters and ferrets, Delta variant remained more dominant.* -
  • The research revealed that the spike gene from Omicron-BA.1 leads to lower replication and pathogenicity in certain mice, while also indicating that this variant may escape immune responses generated by mRNA vaccines, contributing to its dominance over other variants.*
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Celestite (SrSO) precipitation is a prevalent example of secondary sulfate mineral scaling issues in hydraulic fracturing systems, particularly in basins where large concentrations of naturally occurring strontium are present. Here, we present a validated and flexible geochemical model capable of predicting celestite formation under such unconventional environments. Simulations were built using CrunchFlow and guided by experimental data derived from batch reactors.

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