Publications by authors named "Estes N"

Purpose: Psychological safety is critical for fostering well-being. Integral to the mission of academic institutions, trainees are among the most vulnerable to negative workplace experiences, calling for a need to understand factors that contribute to psychological safety in this population. Our objective is to empirically explore trainee psychological safety to inform best practices for training environments.

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Introduction: Real-world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.

Methods: Patients from a large US hospital system undergoing combined LAAO and left-atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs.

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Introduction: Severe obesity presents significant challenges in imaging and delivery of therapy, including pacemaker implant.

Methods And Result: We present our experience implanting a leadless pacemaker (LP) in a severely obese man presenting with heart block. We describe our multidisciplinary approach using right internal jugular venous access and transesophageal imaging in lieu of fluoroscopy which failed to provide workable images in this instance.

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  • The LIVE-LQTS study aimed to investigate whether vigorous exercise increases the risk of ventricular arrhythmias in individuals with congenital long QT syndrome (LQTS) by tracking participants' activity and health events over three years.
  • Among 1,413 participants, 52% engaged in vigorous exercise, and the study found similar rates of serious cardiac events (2.6% in vigorous exercisers vs. 2.7% in non-vigorous) suggesting that vigorous exercise may not significantly increase risk for these individuals.
  • The results had a hazard ratio of 0.97, indicating that vigorous exercisers experienced similar or potentially lower rates of adverse events than those who did not exercise vigorously, providing insight into safe exercise practices for LQ
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Evidence supports that people identifying as a sexual or gender minority (SGMs) experience minority-related stress resulting from discrimination or expectations of prejudice, and that this is associated with increased mental and physical health problems compared to cisgender heterosexuals. However, the biological mechanisms driving minority-related stress impacts remain unknown, including the role of the gut microbiome. Thus, the aim of this study was to determine the relationship between SGM status and gut microbiome health among young adults attending a 4-year university.

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  • The study assessed the long-term effects of weight gain on heart-related issues in over 62,000 adults with atrial fibrillation (AF).
  • It found that 43% of these patients gained weight during the follow-up period, with those gaining more weight being younger, more likely to be women, and having lower income.
  • Increased weight gain was linked to a higher risk of hospitalization for conditions like heart failure, stroke, and myocardial infarction, signaling that weight management is crucial for patients with AF.
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Background: The risk factor (RF) burden, clinical course, and long-term outcome among patients with atrial fibrillation (AF) aged <65 years is unclear.

Methods: Adult (n=67 221; mean age, 72.4±12.

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  • * The study analyzed over 19,000 patients with DD, finding that both low and high RHR were associated with an increased risk of hospitalization for AF, indicating a J-shaped relationship.
  • * Faster RHR also correlated with a higher rate of all-cause death, suggesting RHR may negatively affect health outcomes in patients with DD, warranting further research into RHR modification as a potential preventive measure for AF.
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Background: Left ventricular dysfunction is characterized by systolic and diastolic parameters, leading to heart failure (HF) with reduced or preserved ejection fraction (EF), respectively. The goal of this study is to examine the impact of left ventricular systolic and diastolic dysfunction (DD) on patient outcomes.

Methods And Results: Two cohorts were used in this analysis: Cohort A included 136 455 patients with EF ≥50%, stratified by the presence and grade of DD.

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Background: Implantable cardioverter-defibrillation (ICD) shocks after left ventricular assist device therapy (LVAD) are associated with adverse clinical outcomes. Little is known about the association of pre-LVAD ICD shocks on post-LVAD clinical outcomes and whether LVAD therapy affects the prevalence of ICD shocks.

Objectives: The purpose of this study was to determine whether pre-LVAD ICD shocks are associated with adverse clinical outcomes post-LVAD and to compare the prevalence of ICD shocks before and after LVAD therapy.

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For the first time in 52 years, an American professional football player (Damar Hamlin) collapsed in cardiac arrest during a game, viewed in real-time on national television. The cause of this profound event was commotio cordis, that is, blunt non-penetrating chest blow-initiated ventricular fibrillation triggered by physical contact not considered unusual for football. The athlete survived because of timely cardiopulmonary resuscitation and defibrillation provided by first responders organized by the National Football League.

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Implantable cardioverter-defibrillators (ICDs) represent transformational technology, arguably the most significant advance in cardiovascular medicine in 50 years. The vision and determination of pioneers Mirowski and Mower was fundamental to this monumental achievement, working with limited resources and confronted by skepticism/criticism from medical establishment. The inventors were followed >35 years in which a multitude of innovative clinical scientists and engineers introduced technological advances leading to the sophisticated devices in practice today.

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  • The study investigates whether vigorous exercise increases the risk of ventricular arrhythmias and mortality in individuals with hypertrophic cardiomyopathy (HCM).
  • Researchers enrolled 1,660 participants aged 8 to 60 with HCM or its genetic markers, categorizing them by their exercise levels (sedentary, moderate, vigorous).
  • The primary outcomes included serious events like death and arrhythmias, with findings analyzed by an unbiased committee to evaluate the effects of exercise intensity on these health risks.
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In patients with left ventricular (LV) dysfunction, the risk of death or heart failure hospitalizations (HFHs) increases with worsening ejection fraction (EF). Whether the relative contribution of atrial fibrillation (AF) to outcomes is more pronounced in patients with worse EF is not confirmed. The present study aimed to investigate the relative influence of AF on the outcome of cardiomyopathy patients by severity of LV dysfunction.

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Background: Atrial fibrillation (AF) affects millions of Americans each year and can lead to high levels of resource utilization through emergency department (ED) visits and inpatient stays.

Hypothesis: We hypothesized that referral of patients to a dedicated Center for AF from the ED would reduce costs of care.

Methods: The University of Pittsburgh Center for AF serves as a rapid referral center for patients with AF to avoid unnecessary inpatient admissions and provide specialized care.

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Background: Left ventricular hypertrophy (LVH) is common in patients with atrial fibrillation (AF), however, many antiarrhythmic drugs (AADs) are contraindicated. US guidelines recommend avoiding pure class III antiarrhythmics such as dofetilide in patients with significant LVH due to concern for an increased risk of death, however, clinical data is lacking. We sought to determine if dofetilide use was associated with increased mortality in patients with LVH.

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  • Modern guideline-directed medical therapy (GDMT) significantly improves survival rates for patients with heart failure with reduced ejection fraction (HFrEF) compared to older treatments used in past research.
  • The study analyzed data from nearly 5,000 patients with primary prevention implantable cardioverter-defibrillators (ICDs) and examined how the number of GDMT medications influenced mortality rates over two years.
  • Results showed that each additional GDMT medication lowered the risk of death by 36% for ICD recipients and 30% for CRT-D recipients, suggesting that maximizing GDMT use should be prioritized for improving patient survival.
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