Publications by authors named "Ester Durrego"
Article Synopsis
- Transmission-blocking vaccines (TBVs) are crucial for malaria control, with Pvs28 and Pvs25 proteins as promising candidates against Plasmodium vivax.
- An analysis of global samples revealed low genetic variation in these proteins compared to some merozoite antigens, but they showed as much diversity as others like MSP-8 and MSP-10, especially in Americas and Asia.
- The study found that genetic differences likely stem from positive natural selection, indicating that understanding these variations is essential for developing effective TBVs that utilize Pvs25 and Pvs28.
A monkey's tale: the origin of Plasmodium vivax as a human malaria parasite.
Proc Natl Acad Sci U S A
February 2005
The high prevalence of Duffy negativity (lack of the Duffy blood group antigen) among human populations in sub-Saharan Africa has been used to argue that Plasmodium vivax originated on that continent. Here, we investigate the phylogenetic relationships among 10 species of Plasmodium that infect primates by using three genes, two nuclear (beta-tubulin and cell division cycle 2) and a gene from the plastid genome (the elongation factor Tu). We find compelling evidence that P.
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