Publications by authors named "Ester A M Kouwert"
J Clin Psychopharmacol
December 2023
Article Synopsis
- Methylphenidate (MPH) is commonly prescribed for attention-deficit/hyperactivity disorder, but some patients require unusually high doses, possibly due to genetic differences affecting drug metabolism.
- A study involving three patients taking doses between 180 to 640 mg of MPH found that their plasma concentrations were lower than expected, indicating a faster metabolism of the drug.
- However, genetic testing of the CES1 gene did not reveal any variants that could account for the increased clearance of MPH in these patients, suggesting other factors may be involved in their high dosage needs.
