Publications by authors named "Estelle Charles"
The BDNF Val66Met gene polymorphism is a relevant factor explaining inter-individual differences to TMS responses in studies of the motor system. However, whether this variant also contributes to TMS-induced memory effects, as well as their underlying brain mechanisms, remains unexplored. In this investigation, we applied rTMS during encoding of a visual memory task either over the left frontal cortex (LFC; experimental condition) or the cranial vertex (control condition).
View Article and Find Full Text PDFTranscranial magnetic stimulation (TMS) can interfere with cognitive processes, such as transiently impairing memory. As part of a multi-center European project, we investigated the adaptability and reproducibility of a previously published TMS memory interfering protocol in two centers using EEG or fMRI scenarios. Participants were invited to attend three experimental sessions on different days, with sham repetitive TMS (rTMS) applied on day 1 and real rTMS on days 2 and 3.
View Article and Find Full Text PDFArticle Synopsis
- - Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is an inherited disorder caused by a specific genetic contraction on chromosome 4, and this study aimed to understand how often it manifests in carriers with 6 to 10 repeat units (RUs).
- - The research involved 65 affected patients and 119 relatives, analyzing their clinical status and genetic information, which revealed a 57% overall penetrance of the disease in the studied group.
- - Results indicated that lower penetrance was observed in carriers with more extensive genetic contractions (9-10 RUs) and that women had a lower penetrance compared to men, highlighting the importance for genetic counseling and patient management.