Publications by authors named "Estela Correche"
The chemical synthesis of 4-N-carboxybutyl-5-fluorocytosine (II) in solution phase starting from 5-fluorocytosine and the solid phase synthesis of Arg-Gln-Trp-Arg-Arg-Trp-Trp-Gln-Arg-NH(2) attached to the 4-N-carboxybutyl-5-fluorocytosine residue at the N-terminus of the peptide (III) via peptide bond formation is reported. The target compound exhibited a significant cytotoxic activity against a culture of HepG2 cells. In addition our results demonstrated that this new compound affect cell viability, produce mitochondrial dysfunction as well as interfere with intracellular calcium homeostasis control; leading to cell malfunction and death.
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- The study evaluated the cytotoxic effects of four alkaloids (berberine, canadine, anonaine, and antioquine) on rat hepatocytes and two cell lines (HepG2 and HeLa) and found that berberine, anonaine, and antioquine were significantly cytotoxic, while canadine was not.
- Molecular modeling suggested that the structure of berberine may be responsible for its cytotoxic effects, highlighting its pharmacophoric features.
- Canadine showed significant antioxidant activity and low toxicity, indicating its potential as a novel antioxidant agent worth further research.
There are a large number of species of Antarctic lichens, and several studies describing the secondary metabolites present in these lichens, as well as the advances in understanding the chemistry of these metabolites, have been reported. In addition, some derivatives displaying interesting antibacterial effects have been described. The cytotoxic and apoptotic effects of 15 secondary metabolites (depsides, depsidones and usnic acid) obtained from Continental (Chilean) and Antarctic lichens were evaluated in primary cultures of rat hepatocytes.
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