Biochemical and cellular changes in leukocyte-depleted red blood cells stored for transfusion.

Background: To evaluate biochemical and cellular changes associated with the storage of leukocyte-depleted red blood cells (RBCs).

Methods: We investigated 10 leukocyte-depleted RBC units, randomly chosen from volunteer donors. Every week an aliquot was collected for laboratorial evaluation, which included complete cell blood count, glucose-6-phosphate dehydrogenase (G6PD) activity, extracellular sodium, potassium and pH, membrane-bound hemoglobin (MBH), band 3 profile, and quantification of RBC membrane proteins composition.

[Association between hyperuricemia and insulin resistance].

Introduction: An association between insulin resistance (IR) and cardiovascular risk factors has been widely described. However, the association between IR and hyperuricemia has been less studied. The objective of this study was to describe the prevalence of hyperuricemia in a community sample of Portuguese adults and evaluate its association with IR.