Publications by authors named "Estefania Santos-Mazo"
Metformin, a hypoglycemic drug for Type 2 diabetes mellitus, shows variability in pharmacokinetics and response due to membrane transporters. This study followed 34 Type 2 diabetes mellitus patients on metformin treatment. Genetic variants in 11 metformin transport-related genes were analyzed, revealing associations.
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- Metformin is the primary treatment for type 2 diabetes, but individual responses vary significantly due to factors like age, sex, and ethnicity.
- This study is the first to evaluate how demographic factors and various transporter polymorphisms influence metformin pharmacokinetics in healthy individuals, revealing that adjustments for dose-to-weight ratio are crucial in understanding these effects.
- Findings indicate that multiple patient characteristics must be considered for personalized metformin treatment, as the pharmacokinetics are influenced by a combination of demographics and genetic factors, while certain polymorphisms showed no significant effect.
First clinical and efficacy data on evolocumab in routine clinical practice in endocrinology and nutrition services in Spain: A retrospective observational study (RETOSS-ENDO).
Endocrinol Diabetes Nutr (Engl Ed)
September 2022
Thyroid disorders associated with immune control point inhibitors.
Endocrinol Diabetes Nutr (Engl Ed)
January 2022
Introduction: Immune checkpoint inhibitors (ICPI) have improved progression-free survival in several solid tumors. Side effects are related to overstimulation of the immune system. Thyroid dysfunction (TD) is the most common endocrine immune-related adverse event of ICPI.
View Article and Find Full Text PDFNon-ketotic hyperglycemia has occasionally been associated with various neurological abnormalities including movement disorders. Hyperglycemic hyperosmolar syndrome (HHS) is the second most common cause of hemiballism-hemichorea, which is due to a contralateral putaminal lesion. We describe a 95-year-old woman with HHS who developed hemichorea-hemiballism syndrome due to a putaminal lesion.
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