Publications by authors named "Estefania Garay-Pacheco"
Background: Mesenchymal stromal cells (MSCs) are multipotent cell populations obtained from fetal and adult tissues. They share some characteristics with limb bud mesodermal cells such as differentiation potential into osteogenic, chondrogenic, and tenogenic lineages and an embryonic mesodermal origin. Although MSCs differentiate into skeletal-related lineages , they have not been shown to self-organize into complex skeletal structures or connective tissues, as in the limb.
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- Organ formation starts when cells commit to one of the three germ layers during early embryogenesis, guided by specific gene transcription networks that dictate cell fate and organ development.
- Organoids can be generated from various stem cells to model this process, resulting in smaller, functional organs that mimic their larger counterparts.
- The study proposes using the recombinant limb (RL) assay system to develop skeletal elements in organoids, leveraging embryonic signals to enable the formation of complex skeletal structures from stem cells or progenitor cells for enhanced research.