Understanding WHO SMART Guidelines: Narrative Review of an Innovative Global Digital Health Approach.

The growing challenges of healthcare systems pose a unique opportunity to leverage evidence-based digital health interventions. The WHO's SMART (Standards-based, Machine-readable, Adaptive, Requirements-based, and Testable) guidelines represent a significant advancement in this domain. This paper aims to summarize SMART guidelines authoring and implementation process, drawing on a comprehensive literature analysis.

Urinary Tamm-Horsfall protein excretion is a potential early biomarker of renal distal tubular damage in canine leishmaniosis.

This study evaluates distal tubular damage in early stages of renal disease in dogs with naturally acquired leishmaniosis. Pherograms of urinary proteins separated in vertical electrophoresis system (SDS-PAGE) were evaluated. Peptide fingerprint and fragmentation (MALDI-TOF TOF) identified bands located at 100 and 60 kDa as Tamm-Horsfall protein (THP) and albumin, respectively.

Making causal inferences from transactional data: A narrative review of opportunities and challenges when implementing the target trial framework.

The target trial framework has emerged as a powerful tool for addressing causal questions in clinical practice and in public health. In the healthcare sector, where decision-making is increasingly data-driven, transactional databases, such as electronic health records (EHR) and insurance claims, present an untapped potential for answering complex causal questions. This narrative review explores the potential of the integration of the target trial framework with real-world data to enhance healthcare decision-making processes.

Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60.

Aging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to their antioxidant and anti-inflammatory effects. This study assessed the protective properties of catechin and polyphenon-60 in non-pathologically aged rats regarding visuo-spatial learning and the oxidative status of the frontal cortex.

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Introducción: La contaminación del aire incrementaría el riesgo de infección respiratoria aguda (IRA) en pediatría. Objetivo: evaluar el impacto de la contaminación del aire en las consultas por IRA realizadas en efectores del Gobierno de la Ciudad de Buenos Aires. Método: estudio ecológico, de series temporales.

Impact of Gut Microbiota in Brain Ageing: Polyphenols as Beneficial Modulators.

Brain ageing is a complex physiological process that includes several mechanisms. It is characterized by neuronal/glial dysfunction, alterations in brain vasculature and barriers, and the decline in brain repair systems. These disorders are triggered by an increase in oxidative stress and a proinflammatory state, without adequate antioxidant and anti-inflammatory systems, as it occurs in young life stages.

[Acute respiratory health effects of air pollution on consultations in children under 2 years old].

Introduction: Air pollution would increase the risk of severe infection repiratory in pediatrics. Research Sources: Environmental Protection Agency, National Meteorological. Service and Integral Health History of the Hospital Management System.

Framework to Emulate Spacecraft Orbital Positioning Using GNSS Hardware in the Loop.

The paper presents a framework to emulate spacecraft orbits using GNSS hardware in the loop that enables the evaluation of new orbital positioning algorithms. The framework software generates the spacecraft orbit and the GNSS signals, including the most common perturbations. These signals are modulated and transmitted by a software-defined radio and received by a commercial GPS receiver.

Ligilactobacillus salivarius PS11610 exerts an effect on the microbial and immunological profile of couples suffering unknown infertility.

Problem: Unknown or idiopathic infertility has been associated with urogenital tract dysbiosis, reducing pregnancy and delivery ratios during assisted reproductive treatments (ART). The Ligilactobacillus salivarius PS11610 strain has shown extraordinary antimicrobial activity in vitro against urogenital pathogens as well as other probiotic characteristics. Therefore, an intervention study was performed to evaluate the effect of L.

Randomized, Double-Blind, Placebo-Controlled Study to Assess the Effect of Two Probiotics on the Preterms' Gut Microbiota.

Objective: To evaluate the effect of a new probiotic strain combination, Ligilactobacillus salivarius subsp infantis PS11603 and Bifidobacterium longum PS10402, on gut bacterial colonization of preterm infants.

Methods: A randomized, double-blind, placebo-controlled study was conducted in preterm infants from 28 weeks + 0days to 30 weeks + 6days of gestation. Thirty preterm infants were randomly selected after birth to receive either probiotics or placebo.

Evaluation of a COVID-19 Vaccine Campaign and SARS-CoV-2 Infection and Mortality Among Adults Aged 60 Years And Older in a Middle-Income Country.

Importance: Although there are reports of COVID-19 vaccine implementation in real-world populations, these come from high-income countries or from experience with messenger RNA technology vaccines. Data on outcomes of vaccine deployment in low- or middle-income countries are lacking.

Objective: To assess whether the pragmatic application of the 3 COVID-19 vaccines available in Argentina, 2 of which have no reports of evaluation in real-world settings to date, were associated with a reduction in morbidity, all-cause mortality, and mortality due to COVID-19.

[An algorithm for identifying visits due to pediatric lower acute respiratory infections in electronic clinical records].

Background: Due to ambiguities in terminology, acute lower respiratory infections (ALRI) in childhood are frequently not properly recorded, especially during outpatient visits. A tool that accurately identifies them, would assess the impact on respiratory health of massive harms, and design policies to prevent or mitigate their effects. We aimed to design an algorithm that allows identifying children with ALRI based on data from the electronic clinical record (ECR) of the Government of the City of Buenos Aires (GCBA).

A facility and community-based assessment of scabies in rural Malawi.

Background: Scabies is a neglected tropical disease of the skin, causing severe itching, stigmatizing skin lesions and systemic complications. Since 2015, the DerMalawi project provide an integrated skin diseases clinics and Tele-dermatology care in Malawi. Clinic based data suggested a progressive increase in scabies cases observed.

Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechin in Aged Rats.

A healthy aging process is a requirement for good life quality. A relationship between physical activity, the consumption of antioxidants and brain health has been stablished via the activation of pathways that reduce the harmful effects of oxidative stress, by inducing enzymes such as SIRT1, which is a protector of brain function. We analyzed the cognitive and neurochemical effects of applying physical exercise in elderly rats, alone or in combination with the antioxidant catechin.

Use of alternative care sites during the COVID-19 pandemic in the city of Buenos Aires, Argentina.

Objectives: In large cities, where a large proportion of the population live in poverty and overcrowding, orders to stay home to comply with isolation requirements are difficult to fulfil. In this article, the use of alternative care sites (ACSs) for the isolation of patients with confirmed COVID-19 or persons under investigation (PUI) in the City of Buenos Aires during the first wave of COVID-19 are described.

Study Design: This is a cross-sectional study.

Cognitive and Neurochemical Changes Following Polyphenol-Enriched Diet in Rats.

Dietary recommendations are frequently developed based on nutrient deficiency or prevention of disease, but less attention has been paid to the dietary guidelines to promote brain health. Active and healthy aging is a prerequisite for improving quality of life as people age, and evidence is establishing a relationship between diet and brain health. This work studied the effect of a diet based on foods rich in antioxidants, especially polyphenols, in rats, three days a week for 20 months starting at 14 months.

Remodeling of the Microvasculature: May the Blood Flow Be With You.

The vasculature ensures optimal delivery of nutrients and oxygen throughout the body, and to achieve this function it must continually adapt to varying tissue demands. Newly formed vascular plexuses during development are immature and require dynamic remodeling to generate well-patterned functional networks. This is achieved by remodeling of the capillaries preserving those which are functional and eliminating other ones.

A new robust adaptive mixing control for trajectory tracking with improved forward flight of a tilt-rotor UAV.

A new robust adaptive mixing control (RAMC) is proposed in order to accomplish trajectory tracking of a tilt-rotor unmanned aerial vehicle (UAV) configuration. This kind of system is a hybrid aerial vehicle that combines advantages of rotary-wing aircraft, like hovering flight and vertical take-off and landing (VTOL), and those of fixed-wing aircraft, as improved forward flight. Although the VTOL and cruise flight regimes present different dynamic behaviors, in this work a unified, highly coupled, nonlinear model is developed to cope with the considered tilt-rotor UAV full flight envelope, that is, the axial flight, hovering, transition/cruise and turning flight.

Strategy for the Analysis and Visualization of Electronic Medical Record Data for Public Hospitals in the City of Buenos Aires.

Through the development of a dashboard with participative methodology we present a centralized strategy to analyze and visualize EMRs data for the management of 15 public hospitals from Buenos Aires City. This approach could constitute an efficient option for public health systems from developing countries.

Safety and Drugs: How Do We Record Medication Consumption and Prescription in Electronic Medical Records? A Look on Aspirin.

Background: documentation of aspirin consumption is usually not complete and clear, probably because it's a cheap drug that can be easily acquired.

Objective: To evaluate the quality of the record of aspirin consumption documented in the electronic medical records (EMRs) of a Private University Hospital of Argentina.

Design: Qualitative and quantitative descriptive exploratory study.

Patients' Experience and Assessment on the Transition from Paper to Electronic Medical Records.

By the implementation of the EMR in the Primary Care Centers of the City of Buenos Aires, it has been claimed that there is a need to obtain systematic and accurate information about the assessment that patients have about such incorporation. A qualitative research has been carried out in order to answer this query.

Neural Networks for Cause of Hospitalization and Final Cause of Death Extraction from Discharge Summaries.

Determining the cause of death of hospitalized patients with cardiovascular disease is of the utmost importance. This is usually recorded in free text form. In this study we aimed to develop a series of supervised natural language processing algorithms to extract cardiovascular causes of hospitalization and final causes of death.