What risk do Brucella vaccines pose to humans? A systematic review of the scientific literature on occupational exposure.

Background: Currently, vaccination of livestock with attenuated strains of Brucella remains an essential measure for controlling brucellosis, although these vaccines may be dangerous to humans. The aim of this study was to review the risk posed to humans by occupational exposure to vaccine strains and the measures that should be implemented to minimize this risk.

Methods: This article reviewed the scientific literature indexed in PubMed up to September 30, 2023, following "the PRISMA guidelines".