Publications by authors named "Esteban Rodriguez-Martino"
Article Synopsis
- The study focused on comparing IgG antibody profiles in Puerto Rican individuals who recovered from COVID-19 and those vaccinated with mRNA vaccines, highlighting significant differences in immune responses.* -
- Convalescent individuals showed strong and lasting antibody responses, especially IgG1 and IgG3, while vaccinated individuals primarily exhibited IgG1; those with prior infections and vaccinated had better protection against the Omicron variant.* -
- Following the third vaccine dose, a notable increase in IgG4 levels was observed, linked to long-lasting immune responses, but raised concerns about the over-administration of boosters due to a potential shift towards immunotolerance.*
Article Synopsis
- - The study assesses the humoral response to SARS-CoV-2 variants in inflammatory bowel disease (IBD) patients 60 days after receiving a third vaccine dose (Pfizer-BioNTech or Moderna), given concerns about vaccine effectiveness due to immunosuppression treatments.
- - Out of 56 IBD subjects, 24 individuals failed to achieve effective neutralizing capability against the Omicron variant, and 70% of these individuals were on anti-tumor necrosis factor therapies, with some showing no neutralization ability against other variants as well.
- - In contrast, all healthy control subjects developed detectable antibodies and effective neutralization against all seven variants tested, indicating that IBD patients may have inadequate protection against COVID
Unlabelled: Patients with immune conditions and immune-modifying therapies were excluded from the Covid-19 vaccine trials. Studies have shown conflicting response to different vaccines in persons receiving immune suppressors or biologics. The aim of this study is to evaluate humoral and cellular response to Covid-19 vaccines in patients with Inflammatory Bowel Disease (IBD) using biologic and/or immunomodulatory (IMM) therapies.
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