Publications by authors named "Esteban Roberto Salazar-Petres"
Article Synopsis
- Gestational chronodisruption affects maternal circadian rhythms by inhibiting melatonin, which can lead to negative long-term health outcomes for offspring, particularly in adult male rats.
- The study assessed the effects of chronic photoperiod shifting on mother rats and their female offspring, with a focus on melatonin supplementation to improve maternal health and pregnancy outcomes.
- Results showed that chronic photoperiod shifting disrupted the mothers' circadian patterns and adversely impacted their offspring's hormonal and inflammatory responses, but these negative effects were mitigated by maternal melatonin supplementation.
Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity, which enables glucose to be available in the maternal circulation for transfer to the fetus for growth. To balance this process and avoid excessive hyperglycaemia and glucose intolerance in the mother during pregnancy, maternal pancreatic β-cells undergo remarkable changes in their function including increasing their proliferation and glucose-stimulated insulin secretion.
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