Publications by authors named "Esteban Ribera Pascuet"
Immune reconstitution inflammatory syndrome in HIV-infected patients with Pneumocystis jirovecii pneumonia.
Enferm Infecc Microbiol Clin (Engl Ed)
December 2018
Introduction: The incidence of immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients after an episode of Pneumocystis jirovecii pneumonia (PJP) seems to be lower than with other opportunistic infections. We conducted an observational study in order to determine the incidence, clinical characteristics and outcome of patients diagnosed with PJP-related IRIS.
Methods: We conducted an observational study of HIV patients diagnosed with PJP-related IRIS from January 2000 to November 2015.
Article Synopsis
- The study investigates the relationship between plasma concentrations of lopinavir (LPV) and ritonavir (RTV) in patients, focusing on factors affecting LPV pharmacokinetics (PK) to improve viral suppression.
- It involved 263 patients, analyzing a database of 1110 concentrations to formulate population PK models, using various patient demographic and clinical factors as potential influences.
- The findings resulted in successful population PK models, indicating how different factors like BMI and other drugs affect the clearance rates of LPV and RTV, verified through predictive performance testing.
Standard antiretroviral therapy (ART) consists of a combination of three active drugs. The selection of these drugs varies considerably according to the clinical scenario. The "gold standard" in patients initiating ART is tenofovir (TDF)/emtricitabine (FTC)/efavirenz.
View Article and Find Full Text PDFAtazanavir (ATV) is a protease inhibitor (PI) in which its main qualities, compared to other PI are dosing convenience, good tolerability and excellent metabolic profile. These characteristics makes it more like a nonnucleoside than a PI, but with the increased genetic barrier common to PI. It is indicated in initial treatment, simplification treatment or a change due to toxicity and in first line rescue treatment.
View Article and Find Full Text PDFObjective: To study the prevalence of delayed diagnosis of HIV infection and associated factors.
Methods: A cross sectional study of patients included in the Spanish VACH cohort who had been diagnosed with HIV infection between 1997 and 2002 was performed. Delayed diagnosis was defined as patients diagnosed with HIV infection and AIDS simultaneously or within the first month after the first positive serologic test, or those with a first CD4+ cell count below 200/ml.