Pro-apoptotic and anti-proliferative activities of cassane diterpenoids on squamous carcinoma cells: An in vitro and in silico study.

Squamous carcinoma of the head and neck is characterized by aberrant apoptosis that prolongs the proliferative capacity of the cells and by uncontrolled cell growth. This study aimed to examine the pro-apoptotic and antiproliferative effects of cassane diterpenoids on squamous carcinoma cells . The cytotoxicity of four (4) cassane diterpenoids {Six-cinnamoyl- 7-hydroxyvouacapen-5-ol(1), pulcherrimin A(2), C(3), and E(4)} isolated from C.

Pattern and causes of missed appointments in a Nigerian Psychiatric Hospital: A cross-sectional study.

Psychiatric patients exhibit a higher rate of missed appointments compared to other medical specialities, leading to provider frustration, increased relapse, and suboptimal outcomes. This study investigates the patterns and correlates of missed appointments among outpatients at the Federal Neuropsychiatric Hospital in Calabar, Nigeria. A cross-sectional study involving 403 consecutive outpatient clinic attendees was conducted.

Essential oil composition of L. (passifloraceae) flowers and chemical-biology study of the leaves extracts and isolated compound.

is a climbing herb employed in ethno-medicine for the treatment of various ailments. The essential oil from flowers of was obtained by hydrodistillation. The ethanol extract of the leaves was dissolved in water, then partitioned with -hexane and -butanol to obtain the various fractions; the fractions and isolated compound were subjected to antioxidant activity.

Prevalence and correlates of medical student mistreatment in Nigeria: A narrative review.

Mistreatment in medical education encompasses various forms of abusive behavior, often indicating a disregard for students' dignity and interfering with the learning process. This review paper aims to investigate the prevalence, patterns, and correlates of medical student mistreatment in Nigerian medical education and shed light on its impact on students' well-being. A literature search was conducted in August 2023 using Medline, Google Scholar, and Web of Science databases to identify relevant studies on the mistreatment of Nigerian medical students.

Workforce migration and brain drain - A nationwide cross-sectional survey of early career psychiatrists in Nigeria.

Background: Nigeria's shortage of psychiatrists is exacerbated due to health worker migration.

Aim: This study explores migration experiences and tendencies among early-career psychiatrists in Nigeria.

Methods: We conducted a cross-sectional survey covering Nigeria's six geopolitical zones, using a 61-item online questionnaire assessing short-term mobility, long-term migration experiences and migration attitudes.

The Relative Role of Family Affluence and Social Support on Depression and Self-Esteem among Adolescents in Nigeria: a Cross-Sectional Study.

Objectives: To assess the relative importance of social support and family affluence in depression and self-esteem among adolescents in Calabar, Nigeria.

Methods: This cross-sectional study was conducted among adolescent students in Calabar, Nigeria. Using stratified random sampling, 332 students were selected for participation.

Psychosocial challenges of persons with sickle cell anemia: A narrative review.

Sickle cell anemia (SCA) is a severe form of sickle cell disease that primarily affects black populations and individuals in tropical countries. This condition causes significant morbidity and mortality and leads to a range of psychosocial challenges. A preliminary search was conducted on Ovid Medline and public databases with a combination of Medical Subject Headings keywords, resulting in 368 articles.

Pharmacogenetic testing in psychiatry: Perspective on clinical utility.

Pharmacogenetic studies the influence of inherited characteristics on medication. While different from pharmacogenomics, which is a study of the entire genome in relation to medication effect, their distinction remains inconsistent, and the two terms are used interchangeably. Although the potential of pharmacogenomics in psychiatry is apparent and its clinical utility is suboptimal, the uptake of recommendations and guidelines is minimal and research into PGx is not diverse.

Upper-air meteorological dataset for Uyo, using radiosonde.

Weather pattern anomalies and climate change have greatly impacted human activities and the environment in varying ways. Whether induced naturally or by anthropogenic activities, it remains a menace to global public health. A foreknowledge of the weather/climate change can help in mitigating the impact of disasters emanating from these changes.

Pattern and Sociodemographic Correlates of Job Stress among Staff in a Nigerian Psychiatric Hospital.

Context: Globalization and technological advances are associated with rapid social and economic changes which are accompanied by increased pressures in the work environment. Job stress is a hidden pandemic, especially in developing countries where it remains largely unaddressed.

Aims: The objective is to determine the pattern and sociodemographic correlates of job stress among staff in a Nigerian psychiatric hospital using the Health and Safety Executive (HSE) indicator tool.

and computational studies on the antiglycation activity of compounds isolated from antidiabetic stem bark.

The continuous search for new compounds in natural-based plants is a promising strategy for the prevention of diseases. This work examined antiglycation activity compounds isolated from the antidiabetic extract of stem bark and computational [molecular dynamics (MD)] approach. Phytochemical investigation of ethyl acetate fraction and the application of spectroscopic methods led to the isolation and elucidation of 3 compounds: quercetin (), kaempferol (), and gallic acid ().

Isolation and characterization of bioactive xanthones from Hippocratea africana (Willd.)Loes.ex Engl. (Celastraceae).

Ethnopharmacological Relevance: Hippocratea africana root is used in African folk medicine for the treatment of several ailments, including pain and inflammation.

Aim Of The Study: To isolate anti-inflammatory and analgesic compounds from the roots of H. africana, with accompanying antioxidant potentials.

Isolation and characterization of anti-inflammatory and analgesic compounds from Uapaca staudtii Pax (Phyllanthaceae) stem bark.

Ethnopharmacological Relevance: Uapaca species including Uapacastaudtii Pax (Phyllanthaceae) are used in West Africa ethnomedicine to treat diverse ailments including pile, rheumatism, oedema and wound healing. However, the anti-inflammatory and analgesic potential as well as constituents of the Uapacastaudtii stem bark has not been investigated.

Aim Of The Study: The study was designed to evaluate the anti-inflammatory, analgesic, and antioxidant activities of extract and fractions ofU.

Antiglycation, antioxidant, and cytotoxic activities of root and essential oil composition.

(Annonaceae), is an essential oil bearing plant; the root is acclaimed as an effective remedy for folkloric diabetic therapy. The root extracts were evaluated for composition, antiglycation, antioxidant, and cytotoxicity. Flavonoids, cardiac glycosides, and tannins were relatively high in the alcohol extract; benzyl benzoate (23.

(L.) Link and (L.) H. S. Irwin & Barneby: constituents of fruit essential oils and antimicrobial activity.

and are mostly gathered from the wild for medicinal use and have a disagreeable odour when crushed. The volatile oils isolated from fresh fruits of and were subjected to gas chromatography (GC), gas chromatography-mass spectrometry (GC-MS) and antimicrobial assays. GC and GC-MS analyses permitted the identification of 58 constituents.

Pattern and predictors of Brain Fag syndrome among senior secondary school students in Calabar, Nigeria.

Context: Brain Fag syndrome (BFS) is a culture-bound disorder that is quite common among Nigerian students. It is known to be associated with study difficulty, and in severe cases, discontinuation of education. Little is known about its pattern and predictors among secondary school (SS) students in Calabar.

Characterization and Antioxidant Activity of Volatile Constituents from Different Parts of Aframomum danielli (Hook) K. Schum.

is used in ethno-medicine for the treatment of several ailments and as a traditional food spice. The hydro-distilled leaf, stem, seed, rhizome and pod volatile oils of were subjected to gas chromatography-mass spectrometry (GC-MS) analysis. Free radical scavenging capacity of the volatile oils was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays.

Eryngium foetidum L. Essential Oils: Chemical Composition and Antioxidant Capacity.

essential oils from Nigeria were investigated for the first time in order to ascertain their potency as natural antioxidants. is an aromatic and medicinal herb used in ethno-medicine and as a traditional spice for foods. The hydro-distilled oils of were subjected to gas chromatography-mass spectrometry (GC-MS) analysis.

Phytochemical analysis and antioxidant activity of the seed of Telfairia occidentalis Hook (Cucurbitaceae).

The 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical, nitric oxide, reducing power, hydrogen peroxide scavenging, and total antioxidant activities of the methanol extract, n-hexane, dichloromethane, ethyl acetate, butanol and aqueous fractions of the seed of Telfairia occidentalis were evaluated. Total phenolic content was determined using the Folin-Ciocalteu method. The dichloromethane fraction exhibited the highest DPPH radical scavenging, reducing power and total antioxidant activities.