Publications by authors named "Essid R"

Diagnosis and treatment of nodules remain challenging issues. The aim of this article is to report the technique of real-time navigation using holographic reconstruction technology combined with a robot assisted thoracic surgery (RATS) platform for lung resection in patients with . The pre-surgery 3D planning was based on the chest CT scan.

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  • This study evaluated the antioxidant and antileishmanial effects of essential oil from Ballota (B.) hirsuta leaves, identifying spathulenol and germacrene D as its main components.
  • The essential oil demonstrated moderate antioxidant activity and high antileishmanial effectiveness against both promastigote and amastigote forms of Leishmania, with specific IC values indicating its potency.
  • The study also revealed that B. hirsuta EO primarily inhibits the sterol synthesis pathway and suggested that its main compounds may be promising candidates for developing treatments against leishmaniasis.
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  • Antibiotic resistance and biofilm formation in Gram-negative bacteria pose significant challenges for infection control, particularly through the Quorum Sensing (QS) mechanism.
  • Myrtle leaf extract demonstrated a potent anti-QS effect, inhibiting 80% of violacein production and significantly reducing various virulence factors like biofilm formation and protease activity at sub-MIC concentrations.
  • The study identified three phenolic compounds from the extract, with 3,5-di-galloylquinic acid showing the strongest interaction with the CviR QS receptor, indicating potential for developing new QS inhibitors against resistant pathogens.
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  • * Major compounds identified in the EO included α-pinene and -cadinol, but the oil showed limited antioxidant activity, failing to neutralize certain free radicals effectively.
  • * The EO demonstrated strong leishmanicidal effects against promastigote and amastigote forms, with the components showing better binding to the enzyme CYP51 compared to the conventional drug fluconazole, suggesting it could be a promising alternative treatment for leishmaniasis.
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Unlabelled: This study aimed to assess the antileishmanial activity of biomolecules obtained from L. leaves and twigs recovered from eight Tunisian cultivars. The extraction was first carried out with 80% methanol, and then the obtained extract was fractionated using three solvents of increasing polarity: cyclohexane (CHX), dichloromethane (DCM) and ethyl acetate (EtOAc).

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Aim: The present study aimed to investigate a novel antifungal compound produced by Streptomyces blastmyceticus S108 strain. Its effectiveness against clinical isolates of Candida species and its synergistic effect with conventional antifungal drugs were assessed, and its molecular mechanism of action was further studied against Candida albicans.

Methods And Results: A newly isolated strain from Tunisian soil, S.

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Combination therapy at appropriately suitable doses presents a promising alternative to monotherapeutic drugs. In this study, and essential oils and their major compounds have exhibited substantial leishmaniacidal potential against both promastigote and amastigote forms of . However, they displayed high cytotoxicity against Raw264.

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Nanoencapsulation is widely considered as a highly effective strategy to enhance essential oils' (EO) stability by protecting them from oxidative deterioration and evaporation. The present study aims to optimize and characterize an efficient technique for encapsulating essential oil into chitosan nanoparticles using response surface methodology (RSM). Moreover, the optimized EO nanoparticle was investigated for its antibacterial (against Gram-positive and Gram-negative bacteria), antifungal (against ), and antiparasitic activity (against parasites).

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  • - The study evaluated the antioxidant, antibacterial, antiviral, and anti-inflammatory properties of various parts (flowers, leaves, seeds) of a specific plant using 80% methanol extraction and microdilution techniques.
  • - Flower extracts demonstrated significant antimicrobial effectiveness against Gram-positive bacteria, as well as strong antioxidant and anti-inflammatory properties, with no toxic effects on macrophage cells.
  • - Two beneficial molecules, 12α-hydroxydaturametelin B and daturametelin B, were identified from the flower extract, showing promising potential for treating inflammatory disorders through effective binding with pro-inflammatory agents.
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Purpose: Leishmaniasis is a parasitic disease found in tropical areas, and it affects up to 12 million individuals globally. Chemotherapies now available include drawbacks such as toxicity, high cost, and parasite resistance. This work aimed to evaluate the antileishmanial properties of essential oils (EOs) extracted from aerial parts of Cupressus sempervirens (C.

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  • - The study explored the antibacterial and antileishmanial effects of Micromeria nervosa extracts, identifying ursolic acid as the active compound and examining its molecular mechanism of action.
  • - Ethanol and diethyl ether extracts of the plant were tested, with the diethyl ether extract showing strong antibacterial activity against certain resistant bacteria and significant antileishmanial effects against Leishmania species.
  • - Results suggest that M. nervosa extracts and the identified ursolic acid could serve as potential natural alternatives for treating infections, demonstrating low toxicity against host cells and targeting specific gene expressions in pathogens.
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  • A bio-composite material was developed using sodium purified clay to carry Caraway essential oil (CEO), which shows strong antibacterial and antifungal properties.
  • The key active components in CEO were identified as Carvone and Limonene, demonstrating effective inhibition against Staphylococcus aureus and Candida albicans at specific concentrations.
  • Experimental results confirmed optimal conditions for creating the bio-hybrid, with Carvone showing a much higher adsorption capacity on the clay compared to Limonene, indicating its potential for pharmaceutical applications.
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Current study aims to evaluate the effect of essential oil on the conservation of chicken fillets. Following a screening, was selected for its antimicrobial ( ATCC 29212, MIC < 0.031 mg/mL) and antioxidant (IC = 1000 µg/mL) potentials with no cytotoxicity effect towards murine macrophage cells.

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Primary retroperitoneal cavernous hemangioma is an extremely rare disease in clinical practice. It is classified as a vascular tumor. Only three cases have been reported in the literature.

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Schwannoma is a type of nerve tumor of the nerve sheath. They are preferentially localized on the head, neck, and flexor surfaces of the extremities. Retroperitoneal schwannoma is extremely rare.

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  • * A study analyzed the antibacterial and antibiofilm effects of Peganum harmala seed extract, revealing that its n-butanol extract was more effective against drug-resistant strains than traditional antibiotics.
  • * The active compound identified as harmaline demonstrated both strong antibacterial properties and significant biofilm inhibition, making it a promising candidate for treating P. aeruginosa-related infections.
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The aim of this study was to investigate antimicrobial and antioxidant activities of different fractions obtained from edible Tunisian Ziziphus Lotus leaves of Tozeur region. Different organic extracts were tested: cyclohexane, dichloromethane, ethyl acetate, n-butanol and water. Bio-guided fractionation revealed that dichloromethane fraction is the most active against S.

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Introduction And Importance: Primary adenoid cystic carcinoma (ACC) of the lung is extremely rare. This tumor can be asymptomatic or have non characteristics symptoms, and the diagnosis is often late. The treatment of choice is surgery when it's possible.

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Cyclic lipopeptides produced by Bacillus species exhibit interesting therapeutic potential. However, their clinical use remains limited due to their low stability, undesirable interactions with host macromolecules, and their potential toxicity to mammalian cells. The present work aims to develop suitable lipopeptide-loaded chitosan nanoparticles with improved biological properties and reduced toxicity.

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  • Echium arenarium Guss, a Mediterranean plant known for its healing properties, was found to have strong antioxidant, antibacterial, and antiparasitic effects, but its potential anti-cancer effects were previously unexplored.
  • This study examined the cytotoxic effects and apoptosis pathways of root (EARE) and aerial part (EAAPE) extracts on the U266 human multiple myeloma cell line, revealing that EARE was more effective in reducing cell viability than EAAPE.
  • The research indicated that both extracts induced significant apoptosis in U266 cells by affecting mitochondrial membrane potential and activating caspase pathways, with EARE showing higher total phenolic compounds, which may contribute to its anti-cancer properties.
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  • A study evaluated 450 bacterial strains for their ability to combat bacterial soft rot in potatoes caused by Pectobacterium carotovorum, identifying strain Ar10 as a strong antagonist.
  • Strain Ar10, identified as Bacillus amyloliquefaciens, produced a cell-free supernatant with significant antibacterial activity against various bacteria, showing a killing rate of up to 96% against P. carotovorum.
  • Treatment of potato tubers with strain Ar10 or its supernatant significantly reduced disease symptoms, indicating that the glycolipid compound produced by Ar10 could be a promising alternative for managing potato soft rot.
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  • Researchers isolated a strain of Bacillus amyloliquefaciens, named C5, from olive tree roots, which produces antibacterial biosurfactant lipopeptides.
  • They optimized its antibacterial activity using grape seed flour (GSF) at different concentrations, finding 0.2% GSF yielded the best growth and antimicrobial results, with an MIC of 60 μg/ml.
  • Thin layer chromatography and MALDI-TOF/MS analyses indicated the production of multiple lipopeptides, including surfactin and bacillomycin D, highlighting GSF as an effective and affordable medium supplement for biosurfactant production.
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The use of synthetic food additive and the appearance of antibiotic resistance are at the basis of important human health problems. The substitution of synthetic compounds with new natural substances extracted from plants or microorganisms is therefore the ideal solution to this scourge. The objective of this work was to evaluate the phyto-constituents (polyphenols, flavonoids and condensed tannins), and to test the biological activities (antioxidant, antibacterial and antiviral) of the Ajuga iva (L) aerial part extracts.

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