Acute toxicity effects of ethylene glycol on lethal dose 50 (LD), urine production, and histopathology change renal tubule cell in mice.

Background: The LD (lethal dose causing 50% mortality) of ethylene glycol (EG) and its associated toxicity in mice () were assessed by evaluating kidney function.

Aim: This study aimed to determine the acute toxicity of an oral lethal dose of 50% (LD) of EG, also degeneration, necrosis, and inflammatory cell invasion in kidney tubules of male rats () as an animal model.

Methods: There were 66 DDG (Deutschland Denken Yoken) mice in 11 groups of six in this investigation.