Prostate-specific antigen nadir concentration, hypertension and diabetes as risk factors for biochemical failure after permanent I seed brachytherapy for prostate cancer.

The aim of this study was to evaluate risk factors for biochemical failure (BF) following permanent prostate seed I brachytherapy for prostate cancer. The study reviewed the medical records of 607 patients with biopsy-proven prostate adenocarcinoma who were treated at Oulu University Hospital between 2001 and 2014. Clinical characteristics at diagnosis, treatment-related data and follow-up data were collected to identify potential risk factors for BF, which was defined using the Phoenix criteria [prostate-specific antigen (PSA) increase >2 µg/l from the PSA nadir concentration, which defined as the lowest PSA concentration observed after BT].