Publications by authors named "Essam Abed Elrazaq"
Background: IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of immunostimulatory signals to patients with glioblastoma (GBM). IGV-001 consists of patient-derived GBM cells treated with an antisense oligodeoxynucleotide against insulin-like growth factor 1 receptor (IGF1R) and placed in proprietary biodiffusion chambers (BDCs). The BDCs are then exposed to 5-6 Gy radiation and implanted at abdominal sites for ~48 hours.
View Article and Find Full Text PDFFAN1 removes triplet repeat extrusions via a PCNA- and RFC-dependent mechanism.
Proc Natl Acad Sci U S A
August 2023
Article Synopsis
- Human genome-wide association studies have identified DNA mismatch repair (MMR) genes, along with FAN1, as influential in the age of onset for Huntington's disease, showing contrary effects on CAG triplet repeat expansion.
- FAN1 functions as a nuclease that removes DNA extrahelical structures associated with triplet repeat expansion, and this process is activated by proteins like RFC and PCNA in physiological conditions.
- The study reveals that FAN1 uses a short patch excision-repair mechanism that competes with MMR, providing insight into how FAN1 helps prevent repeat expansion and clarifying the conflicting roles of MMR and FAN1 in Huntington's disease progression.