Induction of ROS mediated genomic instability, apoptosis and G0/G1 cell cycle arrest by erbium oxide nanoparticles in human hepatic Hep-G2 cancer cells.

The remarkable physical and chemical characteristics of noble metal nanoparticles, such as high surface-to-volume ratio, broad optical properties, ease of assembly, surfactant and functional chemistry, have increased scientific interest in using erbium oxide nanoparticles (ErO-NPs) and other noble metal nanostructures in cancer treatment. However, the therapeutic effect of ErO-NPs on hepatic cancer cells has not been studied. Therefore, the current study was conducted to estimate the therapeutic potential of ErO-NPs on human hepatocellular carcinoma (Hep-G2) cells.

Estimation of Calcium Titanate or Erbium Oxide Nanoparticles Induced Cytotoxicity and Genotoxicity in Normal HSF Cells.

Extensive uses of calcium titanate nanoparticles (CaTiO-NPs) and erbium oxide nanoparticles (ErO-NPs) increase their release into the environment and human exposure, particularly through skin contact. However, there are almost no studies available on the effect of these nanoparticles on skin integrity. Therefore, this study was undertaken to estimate CaTiO-NP- or ErO-NP-induced cytotoxicity and genotoxicity in normal human skin fibroblast (HSF) cells.