Novel Clotrimazole and loaded chitosan nanoparticles: Antifungal and wound healing efficiencies.

Chitosan integrated nanoparticles of clotrimazole and Egyptian juice extract was evaluated in order to maximize the antifungal activity and reduce the gross side effects. In the present study Egyptian Thompson Seedless and Clotrimazole (Cz) loaded chitosan nanoparticles (NCs/VJ/Cz) showed a promising antifungal effect with average inhibition zone diameters of 74 and 72 mm against and respectively. NCs/VJ /Cz was stable with significant drug entrapment efficiency reached 94.