Publications by authors named "Esra Zerdali"
Article Synopsis
- Abacavir is a commonly used initial HIV treatment that can cause hypersensitivity reactions (HSR) linked to the HLA-B*57:01 allele, which can be serious and limit treatment options.
- A study in Istanbul involved 867 treatment-naïve HIV patients to assess the prevalence of HLA-B*57:01 and found that 1.6% were positive, with four of those patients switched from abacavir-based therapy.
- This prevalence data is lower than previous reports (3-3.6%) and suggests that HLA-B*57:01 screening is important for effective and safe HIV treatment planning in Turkey.
Introduction: The aim of this national, multicenter, cross-sectional, retrospective chart review study was to determine the proportion of patients in Turkey who received hepatitis C virus (HCV) treatment after receiving positive anti-HCV results during HCV screening.
Methodology: Data related to patients' demographics, laboratory results, time interval from obtaining a positive anti-HCV result to treatment initiation, specialty of the physician requesting anti-HCV screening, and type of hospital were analyzed.
Results: Among 1,000 patients who received a positive anti-HCV result, 50.
Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%.
View Article and Find Full Text PDFIntroduction: For the first time, the accuracy and proficiency of ChatGPT answers on urogenital tract infection (UTIs) were evaluated.
Methods: The study aimed to create two lists of questions: frequently asked questions (FAQs, public-based inquiries) on relevant topics, and questions based on guideline information (guideline-based inquiries). ChatGPT responses to FAQs and scientific questions were scored by two urologists and an infectious disease specialist.
Background: Human immunodeficiency virus (HIV) is still a challenge for children. About 15 to 45% of the HIV positive pregnant women can transmit the virus to their children during pregnancy, delivery and/or breastfeeding. The risk of transmission can be decreased my several measures.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to investigate non-invasive methods for detecting liver fibrosis in chronic hepatitis C patients before and after treatment using direct-acting antivirals (DAAs).
- Conducted with 125 patients over a timeline from 2016 to 2020, various fibrosis scoring methods were utilized to monitor liver condition at multiple points: before treatment, after treatment, and at 12 weeks, 1 year, and 3 years post-treatment.
- Results showed significant reductions in fibrosis scores after treatment, indicating that these serum fibrosis scores can effectively track liver health improvements in chronic hepatitis C patients undergoing DAA therapy.
Hepatitis D virus (HDV) infection represents the most serious form of chronic hepatitis. Turkey is among the countries with high HDV and intermediate hepatitis B virus prevalence. In Turkey, hepatitis B virus (HBV) vaccine series was included in the routine vaccination program in 1998.
View Article and Find Full Text PDFWe aimed to explore the prevalence of prolonged symptoms, pulmonary impairments and residual disease on chest tomography (CT) in COVID-19 patients at 6 months after acute illness. In this prospective, single-center study, hospitalized patients with radiologically and laboratory-confirmed COVID-19 were included. A high proportion of the 116 patients reported persistent symptoms (n = 54; 46.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated trends in the epidemiological profile and clinical findings of newly diagnosed HIV-infected patients over a 16-year period in Istanbul, focusing on 748 patients from 2002 to 2017.
- Key findings indicated an increase in newly diagnosed HIV patients being younger, more likely to be male and single, and more educated in the later years (2010-2017) compared to earlier years (2002-2009).
- Results also showed a higher median CD4 T cell count and a lower percentage of patients with severely low CD4 counts in the 2010-2017 period, alongside a significant shift towards voluntary testing and less heterosexual transmission.
Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting.
Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers.
Background: The number and proportion of elderly patients living with chronic hepatitis C are expected to increase in the coming years. We aimed to compare the real-world efficacy and safety of direct-acting antiviral treatment in elderly and younger Turkish adults infected with chronic hepatitis C.
Methods: In this multicenter prospective study, 2629 eligible chronic hepatitis C patients treated with direct-acting antivirals between April 2017 and December 2019 from 37 Turkish referral centers were divided into 2 age groups: elderly (≥65 years) and younger adults (<65 years) and their safety was compared between 2 groups in evaluable population.
Article Synopsis
- A study was conducted to develop a new risk score, named SAD-60, to predict mortality in hospitalized COVID-19 patients, involving 1,013 participants with an average age of 60.5 years.
- The research found that factors like oxygen saturation, albumin levels, D-dimer, and age were significant predictors of in-hospital death, with 12.2% of patients dying.
- The SAD-60 score demonstrated a better predictive ability for mortality than existing scores such as CURB-65, NEWS2, and qSOFA, suggesting it could be a valuable tool in clinical settings.
Objective: We aimed to determine Hepatitis B virus (HBV) prevalence, immune status, and the prevalence of antibody response in people living with HIV/AIDS (PLWHA) in Istanbul, Turkey.
Methods: The study includes PLWHA aged 18 years and older who were followed-up for at least 6 months from 1997 to 2018.
Results: Of the 653 patients with PLWHA, 99 (15.
Article Synopsis
- - The study focused on determining how common tuberculosis (TB) is among people living with HIV/AIDS (PLWHA) and identifying factors that predict its occurrence.
- - Conducted between 2000 and 2016, the research included 711 adults, revealing that 5.3% had active TB, with significant associations found between TB and low CD4+ counts, high viral loads, and alcohol consumption.
- - The findings suggest that monitoring CD4+ lymphocyte counts and viral loads could help predict TB development, highlighting the need for community initiatives to address alcohol use among PLWHA.
Article Synopsis
- - The study compared clinical, laboratory, and radiological findings between confirmed COVID-19 patients (338) and unconfirmed ones (282) at a single center, involving a total of 620 patients.
- - Confirmed COVID-19 patients had more frequent close contacts with positive cases, and symptoms like myalgia and dyspnea, along with lower blood cell counts, were significant indicators of infection in the univariate analysis.
- - The study concluded that while routine blood tests can help differentiate COVID-19 from other respiratory ailments early on, PCR tests remain essential for an accurate COVID-19 diagnosis.
We aimed to determine the prognostic values of the National Early Warning Score 2 (NEWS2) and laboratory parameters during the first week of COVID-19. All adult patients who were hospitalized for confirmed COVID-19 between 11 March and 11 May 2020 were retrospectively included. Overall, 611 patients were included.
View Article and Find Full Text PDFClinical and microbiological characteristics of Aeromonas bacteremia in Turkey.
Acta Microbiol Immunol Hung
June 2021
We investigated the cases with Aeromonas bacteremia in terms of clinical and microbiological characteristics, underlying disease and mortality rates. Patients with positive blood cultures were included in this research. Aeromonas bacteremia was diagnosed as at least one positive blood culture for Aeromonas species.
View Article and Find Full Text PDFFemale genital tuberculosis (FG-TB) is an important disease leading to substantial morbidity including infertility and abnormal vaginal bleeding. While the incidence of FG-TB is < 1% in a developed area, its incidence is >1% in developing countries. Due to its subtle presentation, many cases are overlooked and diagnosed incidentally.
View Article and Find Full Text PDFWe aimed to determine the predictors of intensive care unit (ICU) admission or death in patients with coronavirus disease 2019 (COVID-19) pneumonia. This retrospective, single-center study included patients aged ≥18 years who were diagnosed with COVID-19 pneumonia (laboratory and radiologically confirmed) between March 9 and April 8, 2020. The composite endpoint was ICU admission or in-hospital mortality.
View Article and Find Full Text PDFObjectives: Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) is a recommended and widely used regimen for HIV infection. In this study, we aimed to determine the efficacy and safety of E/C/F/TAF in people living with HIV (PLWH), who are either treatment-naïve or switched from any tenofovir disoproxil fumarate-containing regimen. For switched patients, we aimed to determine the impact of switching from tenofovir disoproxil fumarate (TDF) to TAF on lipid profile and kidney functions.
View Article and Find Full Text PDFEvaluation of 170 Followed-up Cases Treated for Hydatid Disease: A Multicentre Study.
Turkiye Parazitol Derg
December 2020
Objective: To determine the clinical characteristics of patients with cystic echinococcosis and the diagnostic and therapeutic approaches used.
Methods: This is a multicentre, retrospective study. Patients from six centres who were diagnosed with hydatid cysts in the last five years were evaluated.
Candidemia is a nosocomial infection mostly found in critically ill patients. Our objectives were to evaluate the change in distribution and resistance profile of Candida spp. isolated from candidemic patients in our intensive care unit over two 5-year periods spanning 15 years and to evaluate the risk factors.
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