Publications by authors named "Esra Balcioglu"
Article Synopsis
- Excessive fructose intake during pregnancy is linked to negative outcomes like fetal losses and low birth weight, highlighting its potential risks.
- A study on rat embryos revealed that increased fructose levels (starting at 1 mM) led to reduced protein synthesis, hindered vascular development, and heightened cell death (apoptosis).
- Significant growth and developmental issues, including heart and limb defects, were observed in embryos exposed to fructose, particularly at higher concentrations (5 mM and above).
Article Synopsis
- Ovarian ischemia, often caused by ovarian torsion, is a critical condition impacting women of reproductive age, leading to decreased ovarian reserve; this study explores the effects of boric acid treatment on ovarian damage in female rats during ischemia/reperfusion.* -
- Researchers created seven groups of rats, applying different methods of boric acid administration to assess its impact on histopathological changes, oxidative stress, and DNA integrity after ovarian ischemia and subsequent reperfusion.* -
- Results showed that boric acid significantly mitigated inflammation and preserved ovarian follicle structure, improved biochemical markers like AMH, and reduced oxidative stress and DNA damage, indicating its potential therapeutic effects on ovarian ischemia injuries.*
Article Synopsis
- This study explored the impact of radiation on the bone development of rat fetuses and how melatonin might protect against these effects, using 15 pregnant Wistar albino rats divided into four groups.
- Results showed that fetuses in the radiation group had significantly lower weights and skeletal development compared to the control, with reduced mineral content observed in bone samples.
- The findings suggest that melatonin may offer protective effects against radiation-induced bone development issues in fetuses, contributing to limited existing research on this topic.
Article Synopsis
- Pseudoephedrine (PSE), a common ingredient in cold medications, is widely used by pregnant women to treat colds, with one in four expecting mothers using it.
- A study was conducted on pregnant rats to analyze the impact of various doses of PSE on fetal long bone development through measurements of weights, heights, and bone ossification after cesarean delivery.
- Results showed a decrease in morphometric data, ossification rates, and calcium levels in bones with increasing PSE doses, indicating that PSE usage during pregnancy negatively affects fetal bone growth.
Article Synopsis
- - This study investigates the protective effects of boric acid on female rat oocytes exposed to nonylphenol (NP), highlighting its potential in preserving ovarian quality and function.
- - Histopathological and biochemical analyses revealed that boric acid mitigated tissue damage, restored hormone levels, and provided DNA protection, suggesting its positive impact on ovarian health.
- - The findings indicate that boric acid may effectively counteract the negative effects of NP, reducing oxidative stress and inflammation, and thus plays a protective role against infertility caused by NP exposure.
Article Synopsis
- Paclitaxel is a common cancer treatment known to harm the male reproductive system, prompting research into ways to mitigate its toxic effects using antioxidants like curcumin.
- A study involving 40 male rats tested the protective effects of curcumin against paclitaxel-induced testicular damage, comparing different treatment groups (control, curcumin only, paclitaxel only, and a combination of curcumin and paclitaxel).
- Results showed that curcumin significantly reduced testicular damage and improved testosterone levels in the group receiving both curcumin and paclitaxel, indicating a potential protective role for curcumin in mitigating paclitaxel's adverse effects on the testes.
Article Synopsis
- The study aimed to assess the effects of hyperbaric oxygen therapy (HBO) on ovarian health in a rat model of ovarian insufficiency induced by cyclophosphamide (CYP).
- The research involved three rat groups: control, CYP, and CYP+HBO, with significant changes in follicle counts and hormone levels observed after treatment.
- Results indicated that HBO therapy could help counteract the ovarian damage caused by CYP, potentially offering a new treatment for young females facing ovarian follicle loss during chemotherapy.
Article Synopsis
- The study examined the presence and health risks of 11 pharmaceutical compounds found in fish and shrimp from the Sea of Marmara, focusing on muscle tissues.
- A total of 10 out of the 11 compounds were detected, with ibuprofen being the most prevalent at high concentrations.
- The findings suggest that certain compounds, particularly various forms of estrogen, may pose health risks to humans who consume these seafood, highlighting a potential safety concern related to pharmaceutical contamination.
Article Synopsis
- * Researchers developed gadolinium oxide and gold nanoparticles (GdO@BSA-Au NPs) to create a bimetallic radiosensitizer aimed at improving treatment outcomes.
- * In studies, GdO@BSA-Au NPs increased tumor suppression in breast cancer models when combined with X-ray radiation, leading to improved cancer therapy results through various biological evaluations.
Article Synopsis
- * Pregnant rats were divided into four groups receiving different doses of CBZ, and the researchers measured various bone development indicators, including ossification length, area, and mineral density.
- * Results showed that higher doses of CBZ significantly reduced ossification areas, calcium concentrations, and altered bone structure, indicating potential negative effects on fetal bone development.
Protective effects of melatonin on female rat ovary treated with nonylphenol.
Biotech Histochem
January 2023
We investigated using histochemistry and immunohistochemistry ovarian damage caused by nonylphenol (NP) and the protective effect of melatonin treatment of NP induced ovarian damage. We used 21 female rats divided randomly into three groups: control, NP and melatonin + NP. Histopathological examination of the ovaries, and counting and classification of follicles were performed using Masson's trichrome staining.
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- The study investigates the protective effects of quercetin, an antioxidant, against liver and kidney damage caused by radiation in rats exposed to a high dose of gamma-ray (10 Gy).
- Six groups of male Wistar rats were formed for the experiment: control, sham, quercetin, radiation, quercetin + radiation, and radiation + quercetin, with quercetin administered either before or after radiation exposure.
- Results indicated that radiation caused significant tissue damage in the liver and kidneys, but rats receiving quercetin showed reduced signs of DNA damage and inflammation, suggesting its potential as a protective agent against radiation-induced injuries.
Article Synopsis
- - This study aimed to compare the effectiveness of topical cyclosporine 0.1% and bevacizumab in reducing corneal neovascularization (abnormal blood vessel growth) in a rat model.
- - The experiment involved 30 rats divided into three groups, where one group received bevacizumab, another cyclosporine, and the last isotonic saline treatment over 28 days, followed by examinations and histopathological analysis.
- - Results showed that while both treatments reduced inflammation and blood vessel formation, cyclosporine 0.1% was found to be more effective than bevacizumab in preventing neovascularization and improving collagen formation.
Article Synopsis
- The study explored how umbilical cord-derived mesenchymal stem cells and erythropoietin affect nerve regeneration in rats after a sciatic nerve crush injury.
- The researchers divided rats into five groups to assess the treatments and measured functional recovery and nerve structure over 28 days.
- Results showed that the mesenchymal stem cell group had improved nerve structure, higher axon counts, and overall better recovery compared to the standard crush injury group, indicating the therapies' positive effects on nerve regeneration.*
Article Synopsis
- The study investigates how different doses of gamma radiation affect ovarian health, specifically focusing on ovarian follicle development, inflammation, and apoptosis (cell death) markers in female rats.
- Four groups of Wistar albino female rats were exposed to varying doses of radiation (0, 1, 5, and 10 Gy) to observe the outcomes on ovarian tissue and related biological markers.
- Results showed that higher radiation doses led to significant ovarian damage, reducing the number of ovarian follicles and altering the expression of critical markers linked to inflammation and cell death, indicating a negative impact on ovarian function.
Article Synopsis
- A comparison study analyzed anionic surfactant and phosphate levels in the Turkish Straits System during the fall of 2016 and spring of 2017.
- Results showed higher anionic surfactant concentrations at the exit of the system while phosphate levels were lower, with higher phosphate values at the entrance linked to the eutrophic conditions of the Black Sea.
- The research is significant for informing the Canal Istanbul Project, as the studied locations are near the proposed construction sites, creating a valuable data foundation.
Article Synopsis
- Doxorubicin (DOX) is an effective cancer treatment but can cause liver toxicity, limiting its use.
- The study explored how selenium (Se), an important mineral, can protect liver tissue from the damaging effects of DOX in rats.
- Results showed that Se injections helped prevent liver damage caused by DOX and reduced markers associated with inflammation and cell proliferation, highlighting Se’s protective role in liver health.
Article Synopsis
- * Traditional methods for counting follicles are manual, subjective, and time-consuming, making them inefficient for accurate assessments.
- * This study introduces an automated method using convolutional neural networks (CNN) for follicle counting, which shows results comparable to expert counts and outperforms the previous Faster R-CNN model.
Article Synopsis
- A one-year study conducted in 2017 monitored the concentrations of alkyl benzene sulphonate (LAS), phosphate, and chlorophyll-a in surface water around the Prince Islands, collecting monthly samples from a single station on each island.
- The study found that LAS concentrations ranged from 18.05 to 72.98 μg/L, phosphate from 18.32 to 31.18 mg/L, and chlorophyll-a from 0.31 to 6.35 μg/L throughout the year.
- While there were no significant changes in concentrations within the year (p > 0.05), notable differences were found between the different stations (p < 0.05).
Article Synopsis
- Investigations of total petroleum hydrocarbons (TPHs) and polycyclic aromatic hydrocarbons (PAHs) were conducted in the Turkish Straits System during autumn 2016 and spring 2017.
- TPH levels ranged from 1.7 to 11.6 μg/l, while PAH concentrations varied from 120 to 2912 ng/g, indicating moderate to high pollution, particularly in areas affected by shipping.
- Average petroleum flows were estimated at 1631 tons/year from the Black Sea to the Marmara Sea, and 8484 tons/year from the Marmara Sea to the Aegean Sea, with PAH origins attributed to both pyrolytic and petrogenic sources.
Article Synopsis
- Contrast-induced nephropathy (CIN) is a type of acute kidney damage caused by contrast agents used in medical imaging, and this study investigates the role of HIF-2α levels in rat models of CIN and their response to treatments with N-acetyl cysteine (NAC) and sildenafil.
- The research involved 36 Wistar rats divided into control, CIN, NAC-treated, and sildenafil-treated groups, where they were induced with CIN using iohexol and then analyzed for biochemical changes, including HIF-2α levels, after treatments.
- Findings indicated that both NAC and sildenafil effectively reduced renal damage and lowered HIF-2α levels, suggesting that HIF-2α could serve as a potential biomarker
Article Synopsis
- Ototoxicity, primarily caused by treatment with cisplatin, leads to damage in hair cells and hearing loss, which is a significant issue in patients undergoing serious medical treatments.
- The study aimed to determine if N-acetylcysteine could prevent cisplatin-induced ototoxicity by using auditory tests and examining cochlear samples in rats.
- Results showed that while cisplatin alone led to hearing impairment and cochlear damage, the group given N-acetylcysteine alongside cisplatin exhibited better hearing outcomes and less damage to the cochlea, suggesting it has protective effects.
Article Synopsis
- This study aimed to compare the effects of two treatments, dexamethasone and bevacizumab, on rabbits with a specific type of eye injury.
- Thirty New Zealand rabbits were injured and divided into three groups: one receiving dexamethasone, another receiving bevacizumab, and a control group receiving saline.
- Results indicated that dexamethasone significantly improved clinical and macroscopic scores compared to the control group, with both treatments showing potential to reduce fibrous growth in the eyes after the injury.
Article Synopsis
- * Using a split-face model on 22 sheep, the study found that the bovine-autogenous mixture led to new bone formation earlier and to a greater extent than PRF.
- * By the ninth month, the bovine mixture showed complete integration with host bone, while PRF remnants were still present, indicating the bovine mixture is more effective for sinus-lifting procedures.
Article Synopsis
- - The study focuses on analyzing polycyclic aromatic hydrocarbons (PAHs) in indigenous mussels (Mytilus galloprovincialis) collected from seven stations in Prince Islands in September 2015.
- - Total PAH concentrations in the mussel samples ranged from 664 to 9083 ng/g.
- - The PAH origins were identified as pyrolytic on Büyükada and a mix of pyrolytic and petrogenic on other islands based on various chemical ratios.