Publications by authors named "Esposito K"
Article Synopsis
- The study investigates early postoperative surface deposits on hydrophilic acrylic intraocular lenses (IOLs) using cases from the Altino Ventura Foundation in Brazil and the University of Utah.
- Clinical observations noted that five patients developed IOL surface deposits shortly after surgery, but these deposits resolved without causing inflammation or affecting visual outcomes.
- Laboratory analyses of unused lenses showed similar deposits with a composition mainly of carbon and oxygen, suggesting potential links to the manufacturing process that require further investigation.
Background: Dietary factors and chronic gastrointestinal diseases are frequent determinants of sexual dysfunctions (SD). Whether inflammatory bowel diseases (IBD) are associated with SD is not well known as well as the role of diet and quality of life (QoL).
Objectives: To evaluate the prevalence of SD in a cohort of IBD patients and assess the role of clinical-demographic variables, adherence to Mediterranean diet (MD) and QoL.
Article Synopsis
- Acute kidney disease (AKD) occurs 7 to 90 days after acute kidney injury (AKI) and carries a high risk of developing into chronic kidney disease.
- Current treatment for AKD is non-specific and focuses on preventing further kidney damage through follow-ups, medication management, blood pressure control, nutrition, and avoiding harmful substances.
- New medications like SGLT2 inhibitors and GLP1 receptor agonists are being studied for their potential to help maintain kidney function and prevent the transition from AKD to chronic kidney disease.
Article Synopsis
- The study aimed to explore how seasonal changes impact sleep quality and glucose control in adults with type 1 diabetes (T1D).
- Researchers analyzed data from participants using continuous glucose monitoring (CGM) before and after seasonal transitions, assessing changes in glucose metrics and sleep quality using the Pittsburgh Sleep Quality Index.
- Results indicated that while sleep quality remained stable, glucose metrics worsened during seasonal transitions, with increased glucose monitoring indicators and decreased time in the target range.
Article Synopsis
- The study reviewed complications from percutaneous ethanol injection (PEI) for benign and cystic thyroid nodules, combining data from 48 published studies and an additional 3670 cases from a specific hospital in Italy.
- The overall prevalence of complications was found to be 32%, with the majority categorized as minor (32%) and major complications being rare (2%).
- Most complications, such as local pain (21%) and transient dysphonia (1%), were considered mild and often required minimal or no treatment.
Article Synopsis
- The study assessed whether combining commonly used ultrasound risk stratification systems (RSS) with RAS gene mutations could improve the diagnosis of thyroid cancer in uncertain nodules.
- A total of 124 nodules were evaluated, and the results showed that incorporating RAS mutations did not significantly enhance the diagnostic accuracy of the ultrasound criteria alone.
- The findings suggest that RAS positivity alone is not a reliable indicator for distinguishing between benign and malignant thyroid nodules in the context of these ultrasound evaluation methods.
Article Synopsis
- The study aims to update the approach for using basal insulin (BI) in treating type 2 diabetes (T2D) by gathering expert opinions through the Delphi consensus method.
- A panel of 31 diabetologists evaluated 29 statements related to BI therapy, ultimately agreeing on 26 as relevant, emphasizing the need for timely initiation of BI alongside other treatments.
- The findings suggest that while newer drug options exist, BI therapy remains crucial in T2D management, and second-generation basal insulins are preferred for their improved flexibility and ease of use.
Purpose: Abnormal liver blood tests (ALBTs), neutropenia (NEU) and thymic hyperplasia (TH) are new features of Graves' disease (GD). Our objectives were: (a) to calculate the accuracy of TH in discriminating between Graves' and non-Graves' thyrotoxicosis, compared to ALBTs, NEU and Graves' orbitopathy (GO); (b) to explore the outcome of GD-associated TH and non-GD-associated TH.
Methods: We prospectively analyzed consecutive adult patients with newly diagnosed thyrotoxicosis from January 2018 to June 2023.
Background: The aim of this study was to describe the clinical characteristics of people with diabetic foot ulcer (DFU) according to glucose variability (GV) and to investigate the relationship between GV and DFU outcome in a population with type 2 diabetes (T2D) and DFU.
Methods: This is a retrospective study of 300 individuals aged 64.3 years (181 males) treated for DFU in a tertiary-care center with a regular follow-up for 6 months.
Importance: Peripheral artery disease (PAD) in diabetes may lead to diabetic foot ulcer and lower-extremities amputation. Glucagon-like peptide 1 receptor agonists have proven cardiovascular benefits in trials of people with type 2 diabetes at high cardiovascular risk.
Objective: To examine the effect of liraglutide on peripheral perfusion measured as peripheral transcutaneous oxygen pressure (TcPo2) in individuals with type 2 diabetes and PAD.
Telemedicine for type 2 diabetes during COVID-19 pandemic: experience from a tertiary diabetes center.
Minerva Endocrinol (Torino)
January 2024
Background: Telemedicine was largely employed during COVID-19 pandemic to guarantee continuity of care in a period of dramatic reduction of face-to-face visits. The aim of this study was to describe the clinical characteristics of a cohort of patients with type 2 diabetes followed by tele-visits and to evaluate the changes in the glyco-metabolic control during a 12-month follow-up.
Methods: This retrospective observational study included 136 adults aged >18 years with at least three tele-visits over a 12-month follow-up period, in a Diabetes Center of the Southern Italy, from April 2020 to March 2022.
Two years with GIOIA 'Effects of gliflozins and gliptins on markers of cardiovascular damage in type 2 diabetes': A prospective, multicentre, quasi-experimental study on sodium-glucose cotransporter 2 and dipeptidyl peptidase-4 inhibitors in diabetes clinical practice.
Diabetes Obes Metab
April 2024
Aim: To assess and compare the metabolic and vascular effectiveness of sodium-glucose cotransporter 2 inhibitors (SGLT-2i) and dipeptidyl peptidase-4 inhibitors (DPP-4i) in the clinical practice of patients with type 2 diabetes in Italy.
Materials And Methods: GIOIA is a 2-year prospective, multicentre, quasi-experimental study that enrolled patients with type 2 diabetes initiating SGLT-2i or DPP-4i for inadequate glycaemic control [glycated haemoglobin (HbA1c) >7%] between March 2018 and March 2021. The primary endpoints were changes in markers of organ damage [carotid intima-media thickness (CIMT), albuminuria, myocardial function] and HbA1c from baseline to year 2.
Purpose: The aim of the present study is to evaluate the association of metabolic and glycemic variables with semen parameters in patients with type 1 diabetes (T1D) with and without erectile dysfunction (ED).
Methods: The study population included 88 adults with T1D using a continuous glucose monitoring, of whom 28 with ED (ED group) and 60 without it (NO ED group). All men completed the International Index of Erectile Function (IIEF-5) and underwent body composition analysis (BIA) and semen analysis.
Introduction Young children experiencing head trauma are prone to skull fractures. Pediatric skull fractures are distinct from adults as they have a greater capacity to undergo remodeling. The objective of this study was to evaluate whether children with isolated skull fractures without an underlying brain injury and normal neurological exam require a transfer to a tertiary hospital with pediatric neurosurgery service.
View Article and Find Full Text PDFAims: This study aims at evaluating the trend of glycemic control metrics during the infection of SARS-CoV-2 in individuals with Type 1 Diabetes (T1D) using a Continuous Glucose Monitoring (CGM) system and vaccinated against COVID-19.
Materials And Methods: This is a retrospective study of T1D subjects who got a breakthrough SARS-CoV-2 infection between November 2021 and February 2022. Data of glycemic control of CGM-derived metrics were compared 14 days before COVID-19 (Time 1), 14 days during COVID-19 (Time 2) and 14 days after COVID-19 (Time 3).
Purpose: Our purposes were: 1) to estimate the prediction performance (PP) of cytology in identifying papillary thyroid carcinoma (PTC) subtypes; 2) to explore how the PTC subtypes distribute among the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS) categories.
Methods: Nodules were included if both the histology with the PTC subtype report and the cytology report with the possible PTC subtype were available. The PP was calculated by making the proportion of True positives/False positives+false negatives.
Background: Stem cell transplantation is an emerging therapy for severe cardiomyopathy, proffering stem cell recruitment, anti-apoptosis, and proangiogenic capabilities. Angiogenic cell precursors (ACP-01) are autologous, lineage-specific, cells derived from a multipotent progenitor cell population, with strong potential to effectively engraft, form blood vessels, and support tissue survival and regeneration.
Methods: This IRB approved outcome analysis reports upon 74 consecutive patients who failed medical management for severe cardiomyopathy, and were selected to undergo transcatheter intramyocardial or intracoronary implantation of ACP-01.
Purpose: To assess the magnitude and durability of the metabolic benefits by simplification of complex insulin treatments in patients with type 2 diabetes inadequately controlled by a full basal-bolus insulin regimen. Herein we report the results of the scheduled 2-year extension of the BEYOND trial.
Methods: Originally, 305 participants with inadequate glycemic control (HbA1c > 7.
Purpose: Continuous Glucose Monitoring (CGM) is a key tool for insulin-treated people with diabetes (PwD). CGM devices include both real-time CGM (rtCGM) and intermittently scanned CGM (isCGM), which are associated with an improvement of glucose control and less hypoglycemia in clinical trials of people with type 1 and type 2 diabetes.
Methods: This is an expert position to update a previous algorithm on the most suitable choice of CGM for insulin-treated PwD in light of the recent evidence and clinical practice.
The pathogenesis of post-gastrectomy reactive hyperinsulinaemic hypoglycaemia is not yet fully clarified. Recent studies suggest an up-regulation of the intestinal glucose transporter SGLT-1 aimed to prevent carbohydrate malabsorption. The overexpression of SGLT-1 could therefore represents one of the mechanisms underlying the wide glycemic excursions found in patients after gastrectomy, but studies investigating the use of SGLT-1/SGLT-2 inhibitors in patients with post-gastrectomy reactive hyperinsulinemic hypoglycaemia are very scant in the literature.
View Article and Find Full Text PDFBackground And Objectives: Health-related quality of life (HRQoL) is a patient-reported measure of health status. However, research on the psychometric properties of HRQoL instruments used post-critical care is less common. We conducted a systematic review assessing the psychometric properties of HRQoL instruments used in adult survivors following critical illness.
View Article and Find Full Text PDFContext: Gut hormones seem to play an important role in postprandial bone turnover, which also may be affected by postprandial plasma glucose excursions and insulin secretion.
Objective: To investigate the effect of an oral glucose tolerance test (OGTT) and an isoglycemic intravenous glucose infusion (IIGI) on bone resorption and formation markers in individuals with type 1 diabetes and healthy controls.
Methods: This observational case-control study, conducted at the Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark, included 9 individuals with C-peptide negative type 1 diabetes and 8 healthy controls matched for gender, age, and body mass index.