Publications by authors named "Esposito Ciro"

Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor; over the years, its use in clinical practice has decreased in favor of more recent drugs. However, it is a rather handy drug, which can be useful in several clinical settings when managing critically ill patients. The objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care medicine.

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  • Robot-assisted extravesical ureteral reimplantation (REVUR) is presented as a beneficial alternative to traditional open surgery for children with complex obstructed megaureter (COM), which may require ureteral dismembering or tapering.
  • In a study of 16 pediatric patients (mostly boys), REVUR was successfully performed without complications, with a median surgery time of around 220 minutes and a hospital stay of about 3.8 days.
  • Post-surgery, all patients experienced symptom relief and improved ultrasound results, with only a small percentage facing minor complications, indicating REVUR's effectiveness and safety for treating obstructive ureteral issues.
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Gender inequalities continue to pose a significant issue across various aspects of life, adversely impacting the well-being of both females and males. These disparities often stem from the ingrained gender stereotypes passed down to young individuals through parental guidance, educational systems, and media portrayal. For this reason, within the psycho-pedagogical field, various intervention models have been developed in recent years, leveraging digital tools to combat stereotypes and enhance well-being among adolescents.

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In February 2020, the Italian government started to adopt measures to contain the spread of COVID-19. This emergency had a strong impact on people's lives and daily activities, negatively affecting their well-being. One of the groups of people that suffered the most from the pandemic emergency and the related isolation was university students.

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  • IgA vasculitis (IgAV) is a pediatric disease characterized by skin and systemic symptoms, and researchers conducted comprehensive studies involving genome, transcriptome, and proteome analyses on a large cohort of IgAV patients and controls to better understand the disease mechanisms.* -
  • Significant associations were found with specific genetic risk factors, including two novel non-HLA loci linked to IgA receptor functioning, which may contribute to disease development through altered immune responses.* -
  • Systems biology approaches helped identify key regulatory networks and master regulators in myeloid cells, along with 21 genetic loci that overlap with IgA nephropathy, suggesting shared pathways in these related conditions.*
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Metabolic syndrome (MetS) is a condition marked by a complex array of physiological, biochemical, and metabolic abnormalities, including central obesity, insulin resistance, high blood pressure, and dyslipidemia (characterized by elevated triglycerides and reduced levels of high-density lipoproteins). The pathogenesis develops from the accumulation of lipid droplets in the hepatocyte (steatosis). This accumulation, in genetically predisposed subjects and with other external stimuli (intestinal dysbiosis, high caloric diet, physical inactivity, stress), activates the production of pro-inflammatory molecules, alter autophagy, and turn on the activity of hepatic stellate cells (HSCs), provoking the low grade chronic inflammation and the fibrosis.

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  • Primary vesicoureteral reflux (VUR) is a common condition in children where urine flows backward from the bladder, leading to urinary tract infections and potential kidney damage.
  • The primary goals for treating VUR in kids are to prevent UTIs and reduce the risk of kidney problems, with available management options including antibiotics, surveillance, and various surgical techniques.
  • Ongoing debates focus on the timing of imaging tests and identifying which patients will benefit most from either antibiotics or surgical treatments, with new technologies like artificial intelligence offering future support in decision-making.
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  • The gut microbiota-brain axis connects gut health to brain function, potentially influencing neurodegenerative diseases, particularly multiple sclerosis (MS).
  • MS is characterized by gastrointestinal issues and an altered gut microbiome compared to healthy individuals, which may worsen disease symptoms and progression.
  • The review discusses various dietary and microbiota-based interventions aimed at restoring gut health, which could help prevent or manage MS through symptom relief and slowing disease progression.
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Aims: to measure the clinical impact of contrast-enhanced ultrasound (CEUS) in the diagnosis of -community-acquired pneumonia (CAP), compared to clinical, radiological and ultrasound diagnosis.

Methods: 84 patients (47/37 males/females, mean age:78,57±11,7 Y) with clinical suspicion of pneumonia and with ultrasound findings of peripheral lung lesions, were investigated with CEUS for a better characterization. Final diagnosis of 65 cap was obtained with complete disappearance of symptoms and pulmonary nodule(s); 19 neoplasms: 16 patients performed histologically with bronchoscopy; 3 refused (non-invasive diagnosis with basal CT-scan and positron emission tomography (PET) with fluorodeoxyglucose (FDG)).

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Robot-assisted extravesical ureteral reimplantation (REVUR) was described for the first time in 2004. Since then, the surgical approach of vesicoureteral reflux (VUR) has changed dramatically. The benefits of this technique are great when compared to the laparoscopic or traditional open approaches.

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Background And Aims: Indocyanine Green Fluorescence (ICG-F)- guided surgery is becoming an increasingly helpful tool in pediatric surgical care. This consensus statement investigates the utility of ICG-F in various pediatric surgical applications, primarily focusing on its evidence base, safety, indications, use across different surgical specialties and dosing strategies. The aim is to establish an international consensus for ICG-F use in pediatric surgery.

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  • A 16-year-old girl with Down syndrome experienced frequent vomiting after meals and significant weight loss, leading to further medical evaluation.
  • Diagnostic tests indicated she had hypertrophic pyloric stenosis (HPS), a condition affecting the stomach’s outlet.
  • After unsuccessful endoscopic treatment, she underwent surgery, significantly improving her symptoms and allowing for normal feeding and weight gain six months later.
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  • * A survey completed by 43 participants, including surgeons and faculty, showed that the FTSM was perceived as a good educational tool, with strong support from both novice and experienced surgeons.
  • * The FTSM demonstrated high-fidelity training capabilities that were user-friendly and accessible, but further enhancements are required for continued improvement and efficacy.
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The COVID-19 pandemic drastically affected many areas and contexts of today's society, including school and family. Several studies focused on the worldwide effects of school closures on students' learning outcomes, context, and well-being. However, the data emerging from these studies are often inconsistent and fragmentary, highlighting the need of a comprehensive analysis of the phenomenon.

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This study aimed to report our experience in indocyanine green (ICG) fluorescence-guided surgery (FGS) in pediatric robotics. The data of 55 patients (35 boys and 20 girls), who underwent robotic surgery using ICG fluorescence in three institutions over the last 7 years, were retrospectively reviewed. The following robotic procedures were included: pyeloplasty (n = 21), complex Lich-Gregoir ureteral reimplantation (n = 8), varicocelectomy (n = 7), adnexal pathology resection (n = 8), partial nephrectomy (n = 4), nephrectomy (n = 4), renal cyst removal (n = 2), and excision of prostatic utricle (n = 1).

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  • - HIF-PHIs are newly developed drugs aimed at treating anemia related to chronic kidney disease (CKD) by enhancing the body's erythropoietin production and improving iron absorption.
  • - Recent studies suggest that HIF-PHIs are as effective and safe as standard treatments for CKD-related anemia, though long-term effects, especially regarding potential risks like cancer and cardiovascular events, remain uncertain.
  • - The Italian Society of Nephrology has endorsed a position paper to adapt KDIGO's recent findings about HIF-PHIs to Italy, considering their effectiveness, safety, and application in specific patient groups.
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  • - Palliative dialysis is a specialized form of renal therapy for patients in critical health stages or at the end of life, focusing on tailored treatments rather than standard dialysis methods due to severe medical conditions and complications.
  • - The document emphasizes the importance of supportive care and shared decision-making between healthcare providers and patients, highlighting a comprehensive evaluation and integration of patient preferences in the treatment plan.
  • - A proposed framework aims to guide nephrologists in providing appropriate treatments for fragile patients, aiming to enhance their quality of life, reduce the need for hospitalization, and promote care at home, addressing a growing need in nephrology practice.
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  • Recent research highlights the importance of understanding changes in higher education and their effects on academic workers' well-being, particularly in relation to stress and job satisfaction.
  • The study focuses on social factors that can improve the well-being of university staff, utilizing data from 198 workers at the University of Foggia in Southern Italy.
  • Key findings suggest that strong social relationships, organizational identification, and attachment to the local community significantly enhance the overall well-being of academics, emphasizing the importance of social connections both inside and outside the university.
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  • - This study evaluated how voiding cystourethrography (VCUG) affects outcomes for patients with duplex system ureterocele (DSU) who underwent endoscopic decompression (ED), involving 75 patients divided into three groups based on their VCUG results.
  • - The results indicated that patients with preoperative vesicoureteral reflux (VUR) had a significantly higher secondary surgery (SS) rate (82%) compared to those without VUR (32%) and those who didn't have a VCUG (25%).
  • - The findings suggest that while patients without VUR and those without a VCUG had similar outcomes, ongoing monitoring through VCUG could be useful for symptomatic patients after ED, and pre
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  • This study compared robotic-assisted varicocelectomy (RAV) and laparoscopic varicocelectomy (LV) in 40 pediatric patients over two years, focusing on techniques and outcomes.
  • Results showed that while both methods were effective, LV had a significantly shorter average operative time (20 min) compared to RAV (34.5 min), better cosmetic results, and lower total costs (€1,587.07 vs. €5,650.31).
  • The conclusion indicates that while RAV is a safe option, laparoscopic techniques are preferable for treating pediatric varicocele due to their efficiency and cost-effectiveness.
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  • The study focused on pediatric patients with anal fistula treated using video-assisted anal fistula treatment (VAAFT) and assessed the effectiveness of ozonide oil for postoperative wound dressing.
  • A total of 33 VAAFT procedures were conducted on 30 children, with a median age of 5.7 years, and the majority of cases were idiopathic in nature.
  • Results indicated that VAAFT is a safe and effective treatment, with a median healing time of 28 days and low recurrence rates, although further studies are needed for more comprehensive conclusions.
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