Publications by authors named "Espinola-Klein C"
Article Synopsis
- * There were five in-hospital deaths among ICU patients (3.5% fatality rate) compared to three in non-ICU patients (0.1%), indicating significantly higher risks for those admitted to ICUs.
- * Significant factors leading to ICU admission included obesity, diabetes, pneumonia, ARDS, and other comorbidities, highlighting the importance of existing health conditions in pediatric COVID-19 cases.
Article Synopsis
- * A study of 1,166,848 hospitalizations from 2005 to 2020 found that the prevalence of sarcopenia in PAD patients increased from 0.05% to 0.34%, with those affected experiencing more comorbidities and a higher likelihood of complications.
- * Patients with sarcopenia received fewer effective treatments for PAD and had increased rates of amputations, severe cardiovascular events, and in-hospital mortality, highlighting the need for improved recognition of sarcopenia in clinical settings. *
Background: Pulmonary embolism (PE) is a potentially life-threatening condition. Admission and treatment in the intensive care unit (ICU) is an important element in critically ill PE patients.
Objectives: We aimed to identify risk factors for ICU admission and differences in patient profiles regarding risk factors and comorbidities between PE patients who had to be admitted to an ICU and those who were treated in a normal ward without ICU.
Background: Although pulmonary embolism (PE) and sarcopenia are common diseases, only a few studies have assessed the impact of sarcopenia in PE on usage of reperfusion treatments in PE.
Methods: All hospitalizations of PE patients aged ≥75 years 2005-2020 in Germany were included in this study and stratified for sarcopenia. Impact of sarcopenia on treatment procedures and adverse in-hospital events were investigated.
Background: Lower extremity peripheral artery disease frequently presents with calcifications which reduces the accuracy of computed tomography (CT) angiography, especially below-the-knee. Photon-counting detector (PCD)-CT offers improved spatial resolution and less calcium blooming. We aimed to identify the optimal reconstruction parameters for PCD-CT angiography of the lower legs.
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- Acute pancreatitis (AP) is linked to a higher risk of venous thromboembolism (VTE), which significantly increases the likelihood of death in hospitalized patients.
- A study analyzed over 797,000 AP hospitalizations in Germany from 2005 to 2019, revealing a VTE incidence of 1.8%, particularly affecting patients in their 50s and 60s.
- Key risk factors for VTE included cancer, undergoing surgery, and heart failure, with patients experiencing VTE having an over threefold increase in the case-fatality rate compared to those without it.
Peripheral arterial occlusive disease (PAOD) is a frequent manifestation of atherosclerosis with a high risk of cardiovascular events (myocardial infarction, stroke, amputation, cardiovascular death). A distinction is made between the stable form of intermittent claudication and chronic limb-threatening ischemia (CLTI, pain at rest, wounds). The most frequent risk factors are diabetes mellitus and smoking.
View Article and Find Full Text PDFDeep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term.
View Article and Find Full Text PDFBackground: Short-term outcomes of pulmonary embolism are closely related to right ventricular dysfunction and patient's hemodynamic status, but also to individual comorbidity profile. However, the impact of patients' comorbidities on survival during pulmonary embolism might be underrated. Although the Charlson Comorbidity Index (CCI) is the most extensively studied comorbidity index for detecting comorbidity burden, studies analyzing the impact of CCI on pulmonary embolism patients' survival are limited.
View Article and Find Full Text PDFExercise Therapy for Chronic Symptomatic Peripheral Artery Disease: A Clinical Consensus Document of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases in Collaboration With the European Society of Vascular Medicine and the European Society for Vascular Surgery.
Eur J Vasc Endovasc Surg
February 2024
Article Synopsis
- Guidelines worldwide endorse exercise as a key treatment for patients with lower extremity peripheral artery disease (PAD).
- Structured exercise programs yield the best outcomes, and this paper aims to help establish these programs for patients with chronic PAD.
- It discusses specific exercise protocols, assesses patient outcomes based on evidence, and addresses disparities in access to supervised programs across Europe, pointing out areas needing further research.
Article Synopsis
- Exercise is highly recommended globally as an essential part of managing lower extremity peripheral artery disease (PAD) to improve patient outcomes.
- This paper aims to help clinicians create effective structured exercise programs tailored for patients with symptomatic chronic PAD, detailing various training protocols and assessment methods.
- It also addresses the unequal access to supervised exercise programs across Europe and points out the need for more research in this area.
Article Synopsis
- Exercise is essential for managing lower extremity peripheral artery disease (PAD), and guidelines worldwide strongly support its use.
- A structured exercise program is crucial for achieving the best results in patients with symptomatic chronic PAD, with various training protocols outlined.
- The document also addresses disparities in access to supervised exercise programs in Europe and identifies areas where more research is needed.
The quality of vascular care has significantly improved in part by the expansion of endovascular techniques for the treatment of symptomatic peripheral artery disease (PAD) in recent years. In Germany these are primarily provided by the three disciplines of vascular surgery, angiology, and interventional radiology (IR). However, the relative contribute of angiologists to the total number of cases performed is unknown.
View Article and Find Full Text PDF(1) Background: Endothelial dysfunction initiates cardiovascular pathologies, including peripheral artery disease (PAD). The pathophysiology of impaired new vessel formation in the presence of angiogenic stimuli, such as ischemia and inflammation, is unknown. We have recently shown in mice that reduced endothelial protein C receptor (EPCR) expression results in defective angiogenesis following experimental hindlimb ischemia.
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- Peripheral arterial disease (PAD) is a condition indicating widespread artery hardening and increases the risk of heart-related issues.
- PAD is frequently not recognized or treated effectively in medical settings, leading to more severe health problems.
- Early detection of PAD is crucial, particularly for diabetics, to ensure timely and appropriate treatment.
Background: Diabetes mellitus (DM) represents a relevant risk factor regarding morbidity and mortality worldwide. However, only limited data exist regarding the impact of DM on the clinical outcome of patients with COVID-19 infection.
Methods: All hospitalized patients with confirmed COVID-19-infection (ICD-code U07.