Publications by authors named "Esperanza Bueno-Juana"
Article Synopsis
- The study investigates how echocardiography can help identify cardiac amyloidosis (CA) in patients with left ventricular hypertrophy (LVH) who are experiencing heart failure (HF) decompensation.
- Out of 85 patients, 49 were diagnosed with CA, with specific echocardiographic measurements showing significant differences between those with CA and those without.
- Key features associated with CA included increased interventricular septum thickness, reduced left ventricular cavity size, and altered right ventricular function, emphasizing the role of echocardiography in diagnosing this condition.
Article Synopsis
- Transthyretin amyloidosis (ATTR) can be classified into wild-type (ATTR-wt) and hereditary forms (ATTR-m), with hereditary cases showing autosomal dominant inheritance.
- ATTR is often underdiagnosed but is becoming recognized as a significant cause of heart failure, particularly with preserved ejection fraction.
- A study evaluated High-Resolution Melting (HRM) analysis for detecting TTR mutations in patients suspected of having ATTR-m, finding it to be an effective and accurate diagnostic method, aligning 100% with TTR gene sequencing results.
Transthyretin amyloidosis (ATTR amyloidosis) is a rare disease characterised by extracellular deposition of amyloid fibrils composed by transthyretin. ATTR amyloidosis can be sub-classified as wild-type ATTR (ATTR-wt) or as hereditary amyloidosis (ATTR-m); the prevalence of both types are likely underestimated. There are tools that can help us to study ATTR-m, as gnomAD database.
View Article and Find Full Text PDF