Publications by authors named "Espen H Hansen"
As the natural producer of acarbose, sp. SE50/110 has high industrial relevance. Like most Actinobacteria, the strain carries several more putative biosynthetic gene clusters (BGCs) to produce further natural products, which are to be discovered.
View Article and Find Full Text PDFThe diatom lipidome actively regulates photosynthesis and displays a high degree of plasticity in response to a light environment, either directly as structural modifications of thylakoid membranes and protein-pigment complexes, or indirectly via photoprotection mechanisms that dissipate excess light energy. This acclimation is crucial to maintaining primary production in marine systems, particularly in polar environments, due to the large temporal variations in both the intensity and wavelength distributions of downwelling solar irradiance. This study investigated the hypothesis that Arctic marine diatoms uniquely modify their lipidome, including their concentration and type of pigments, in response to wavelength-specific light quality in their environment.
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- The text indicates a correction has been made to an article published in the journal Frontiers in Microbiology.
- The article's DOI is 10.3389/fmicb.2023.1130018, providing a unique identifier for locating the original research.
- Details about the nature of the correction or changes made to the article are not specified in the text.
Article Synopsis
- The study focuses on suomilides and banyasides, unique non-ribosomal peptides produced by cyanobacteria in the Nostocales order, featuring a specific complex core structure.
- Four new suomilides (B-E) were isolated and analyzed, showing differences from the original suomilide A in their glycosyl groups.
- Despite testing these compounds for anti-proliferative, anti-biofilm, and anti-bacterial properties, no significant activity was observed, while the sequencing of the contributing organism's genome suggested a potential biosynthetic pathway for suomilides.
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- Bacterial symbionts from marine invertebrates have the potential to produce new pharmaceutical compounds that may help address multi-drug resistant infections and various diseases.
- This study identified antibacterial and cytotoxic properties in a marine symbiont, specifically finding that it has effects on Gram-positive bacteria and human melanoma cells.
- The research involved isolating cholic acid and 3-oxo cholic acid, and although a full pathway for cholic acid synthesis was not confirmed, genes related to bile acid transformation were identified, highlighting the need for further exploration of these bacteria's bioactive capabilities.
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- * Researchers explored how different methods and sources, like sediments and animals, influenced the success of isolating actinobacteria and noted a surprising presence of unwanted bacilli.
- * An experimental protocol was tested for efficient cultivation and extraction, revealing that the heat-shock method effectively enriched spore-forming bacteria, while UHPLC-MS/MS analysis identified potential bioactive compounds.
Article Synopsis
- * This compound shares similarities with an earlier compound named chlovalicin and is the first of its kind from its genus, also being the first fumagillin/ovalicin-like compound documented in Basidiomycota.
- * Chlovalicin B showed weak cytotoxic effects on a human melanoma cell line but demonstrated no significant antibacterial or antifungal activities, nor did it affect biofilm formation or cytokine production in human cells.
Article Synopsis
- * A marine fungus from the Lulworthiaceae family was studied, leading to the discovery of a novel compound called lulworthinone, which demonstrated antibacterial activity against various resistant strains and antiproliferative effects on specific cancer cell lines.
- * The compound was structurally characterized using advanced spectroscopic methods and showed potential for inhibiting bacterial biofilm formation, but did not affect established biofilms or exhibit antifungal properties.
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- A new genus of Gram-negative bacteria was discovered in 2005, comprising 12 species that have not been previously studied for their potential to produce secondary metabolites.
- In a project screening Arctic marine bacteria, a specific strain (M09B143) was cultivated and tested, leading to the identification of one fraction with antibacterial properties.
- Two novel compounds, isobranched lyso-ornithine lipids, were isolated and showed activity against a Gram-positive bacterium and cytotoxic effects on human melanoma cells.
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- Marine fungi are underrepresented in global genome projects, and the 1000 fungal genomes (1KFG) initiative aims to explore their diversity and potential industrial applications.
- The study focused on three marine fungi, identifying a new species, E. atlantica, known for its ability to decompose various marine biomaterials, while other specimens showed fewer biosynthetic capabilities.
- The research produced valuable genomic data for fungi exclusively found in marine environments, highlighting their ecological and industrial significance and setting the stage for further studies on their unique traits and functions.
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- The study explores the "One Strain Many Compounds" (OSMAC) approach to discover bioactive compounds by introducing stress factors, focusing on how grazing pressure impacts the metabolome of marine diatoms when co-cultured with zooplankton.
- In large-scale bioreactor experiments, the researchers found that diatom extracts exhibited higher bioactivity in assays against human lung cells when under grazing stress from zooplankton, although it did not significantly impact biofilm formation or bacterial growth.
- The analysis of metabolic profiles revealed distinct differences between the diatom's chemical outputs in monoculture versus co-culture, suggesting that grazing stress alters diatom biochemistry and could enhance the OSM
Article Synopsis
- - Siderophores are compounds that bacteria produce to capture iron, especially when it's scarce, which is crucial for many life processes.
- - Researchers isolated a rare siderophore called serratiochelin A from a co-culture of two marine bacteria species under iron-limited conditions, marking its first identification outside of its original source.
- - While the degradation product serratiochelin C was observed during the isolation process, serratiochelin A showed no bioactivity in certain tests, whereas serratiochelin C inhibited growth in both eukaryotic and prokaryotic cells.
Article Synopsis
- * This research focused on extracting and analyzing fractions from a specific diatom known for its anti-inflammatory properties, identifying five distinct fractions.
- * Two fractions (C and D) were particularly effective in inhibiting TNF-⍺ release, and specific compounds like lysophosphatidylcholines and pheophorbide a were linked to this anti-inflammatory activity, highlighting the need for careful analysis before isolating bioactive compounds.
Article Synopsis
- Two bacterial isolates from the Barents Sea produced extracts with antibacterial properties, leading to the discovery of a lipopeptide named Lipid 430.
- Mass spectrometry and nuclear resonance spectroscopy helped identify Lipid 430's structure and demonstrated its antibacterial activity, as well as a cytotoxic effect on the A2058 human melanoma cell line.
- The study revealed that Lipid 430's mechanism against melanoma cells is more complex than just breaking down cell membranes, as it did not cause immediate cell lysis.
Article Synopsis
- - The study explores the potential of the breitfussin family of natural products, featuring a unique indole-oxazole-pyrrole structure, as effective inhibitors of kinases, which are important in cancer treatment.
- - Six new halogenated variants, breitfussin C-H, were discovered from Arctic marine hydrozoans, with some demonstrating selective cancer cell line inhibition, particularly showing a low IC value of 340 nM against the challenging MDA-MB-468 triple negative breast cancer cell line.
- - Further testing indicated that breitfussins bind competitively to the ATP binding pocket of specific kinases (PIM1 and DRAK1) with low IC values, suggesting their potential for