Publications by authors named "Esmerij P van der Zanden"
Background: Adalimumab is administered via a pre-filled syringe or spring-loaded pen. In a previous study in Crohn's disease, higher drug levels were observed in syringe users. The aim of this study was to evaluate the impact of delivery device on adalimumab drug levels in patients with Crohn's disease.
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- - Smoking influences the disease progression of inflammatory bowel disease, possibly through the immunomodulatory effects of nicotine on nicotinic acetylcholine receptors (nAChRs), particularly the α7 subtype (CHRNA7) and its variant (CHRFAM7A).
- - A study involving the THP-I monocyte cell line and human participants found that repeated nicotine exposure increased CHRNA7 expression, enhancing the ability of certain agonists to lower TNF levels, a key inflammatory marker.
- - Results showed that CHRNA7 was higher in smokers' blood monocytes, suggesting that smoking may alter immune responses, while CHRFAM7A and another receptor (CHRNB2) were not influenced by nicotine exposure. *
The role of STAT3 in infectious diseases remains undetermined, in part because unphosphorylated STAT3 has been considered an inactive protein. Here, we report that unphosphorylated STAT3 contributes to cholinergic anti-inflammation, prevents systemic inflammation, and improves survival in sepsis. Bacterial endotoxin induced STAT3 tyrosine phosphorylation in macrophages.
View Article and Find Full Text PDFBackground And Purpose: In various models vagus nerve activation has been shown to ameliorate intestinal inflammation, via nicotinic acetylcholine receptors (nAChRs) expressed on immune cells. As the alpha7 nAChR has been put forward to mediate this effect, we studied the effect of nicotine and two selective alpha7 nAChR agonists (AR-R17779, (-)-spiro[1-azabicyclo[2.2.
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- The vagus nerve regulates macrophage activity by releasing acetylcholine (ACh), which interacts with nicotinic acetylcholine receptors (nAChR) to influence immune responses, particularly in cases of intestinal inflammation.
- Research showed that activating nAChR enhances the ability of intestinal and peritoneal macrophages to engulf particles, using a specific receptor type (alpha4/beta2) and involving recruitment of a protein called Dynamin-2.
- In addition to promoting phagocytosis, ACh also reduces harmful inflammatory responses while boosting the production of anti-inflammatory interleukin-10, suggesting that vagus nerve activity could help maintain intestinal health and balance immune responses.
Objective: Recent studies have suggested an important role for neurotransmitters as modulators of inflammation. Therefore, we undertook this study to investigate the expression of the alpha7 subunit of the nicotinic acetylcholine receptor (alpha7nAChR) and its function in rheumatoid arthritis (RA).
Methods: The potential role of the alpha7nAChR in modulating proinflammatory cytokine expression in fibroblast-like synoviocytes (FLS) was identified by screening an adenoviral short hairpin RNA (Ad.
Acetylcholine released by efferent vagus nerves inhibits macrophage activation. Here we show that the anti-inflammatory action of nicotinic receptor activation in peritoneal macrophages was associated with activation of the transcription factor STAT3. STAT3 was phosphorylated by the tyrosine kinase Jak2 that was recruited to the alpha7 subunit of the nicotinic acetylcholine receptor.
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