The role of eugenol and ferulic acid as the competitive inhibitors of transcriptional regulator RhlR in .

Search inhibitors of Quorum Sensing (QS) in are challenging to find therapies due to the broad antibiotic resistance. Therefore, this study aimed to probe ten aromatic compounds as inhibitors of three transcriptional regulators of QS in . The methodology consisted in determining the Binding Gibbs Energy (BGE) with software Chimera (tool vina) and Mcule, comparing the averages by the Tukey method (p≤0.

Mechanisms of Inhibition of Quorum Sensing as an Alternative for the Control of and .

Quorum sensing (QS) is a process of cell-cell communication for bacteria such as and that cause foodborne diseases, with the production, release, and detection of autoinducer (AI) molecules that participate in the regulation of virulence genes. All of these proteins are useful in coordinating collective behavior, the expression of virulence factors, and the pathogenicity of Gram-negative bacteria. In this work, we review the natural or synthetic inhibitor molecules of QS that inactivate the autoinducer and block QS regulatory proteins in and .