The study aimed to evaluate the prevalence of neuronal antibodies in patients diagnosed with neurodegenerative dementia, as these can mimic conditions like autoimmune encephalitis (AIE) and potentially respond to immunotherapy.
In a cohort of 920 dementia patients, only 0.8% were found to have neuronal antibodies, along with a variety of atypical symptoms that distinguished them from typical neurodegenerative cases.
None of the patients exhibited significant MRI abnormalities associated with AIE, and only one patient showed an atypical change in cerebrospinal fluid, emphasizing the complexity of diagnosing these conditions.