Publications by authors named "Esmatjes E"
Article Synopsis
- The study investigates the link between cumulative tobacco consumption and atherosclerosis in patients with type 1 diabetes, focusing on its potential to enhance the Steno T1 Risk Engine (ST1RE) for identifying arterial plaques.
- A total of 584 type 1 diabetes patients were examined, revealing a 40.9% prevalence of plaques, with cumulative tobacco use correlating with higher plaque counts even after adjusting for various health factors.
- Although adding cumulative tobacco consumption to the ST1RE didn't significantly improve plaque identification overall, it did enhance detection specifically in active smokers, suggesting further research is necessary to understand its implications for atherosclerosis risk in type 1 diabetes.
Article Synopsis
- This study investigates how severe hypoglycemia (SH) and awareness of hypoglycemia are related to the early stages of atherosclerosis in individuals with type 1 diabetes (T1D).
- It involved 634 patients without cardiovascular disease, evaluating their risk factors and using ultrasound to detect carotid plaque.
- Results indicate that both a history of SH and hypoglycemia awareness scores are linked to preclinical atherosclerosis, suggesting they could help identify patients needing more aggressive treatment even when overall cardiovascular risk is low.
Article Synopsis
- People with type 1 diabetes (T1D) face a higher risk of cardiovascular disease (CVD), and this study explored how following the energy-restricted Mediterranean diet (erMEDd) affects carotid atherosclerosis.
- A total of 401 T1D patients were studied, and those with carotid plaques displayed lower adherence to the erMEDd compared to those without plaques.
- The results indicate that better adherence to the Mediterranean diet is linked to less atherosclerosis, emphasizing the need for encouraging healthy eating habits in T1D patients, especially those at risk for CVD.*
Article Synopsis
- Women with type 1 diabetes face a higher risk of cardiovascular events than men, and this study examines how preeclampsia and childbirth (parity) influence this discrepancy.
- The study analyzed 728 participants, focusing on carotid plaque presence and cardiovascular risk using standardized ultrasonography and the Steno T1 Risk Engine.
- Findings showed that women without a history of preeclampsia had a lower risk for carotid plaque compared to men, but adding obstetric factors to cardiovascular risk assessment did not enhance prediction accuracy.
Article Synopsis
- The study aimed to evaluate the effectiveness of the arterial splenomesenteric anastomosis (ASMA) technique in reducing arterial complications for pancreas transplant recipients.
- Out of 407 pancreas transplants analyzed, ASMA was used in 92.4% of cases, leading to a lower rate of arterial complications compared to the iliac Y-graft technique.
- The findings suggest ASMA is a safe and effective method, proposing it as a preferred option for arterial reconstruction in pancreas transplants.
Article Synopsis
- Recent studies show a link between immune responses and cardiovascular disease (CVD), but data on type 1 diabetes (T1D) is limited; this study explores the connection between inflammatory markers and early signs of atherosclerosis in T1D patients.
- The research involved 602 T1D individuals without CVD; diagnostic tools examined carotid plaques, and various inflammatory markers, such as leukocyte count and the neutrophil-to-lymphocyte ratio (NLR), were analyzed for their relationship to plaque presence.
- Findings revealed that a higher NLR was significantly associated with increased carotid plaque burden, highlighting the potential impact of innate immunity on atherosclerosis in those with T1D.
Introduction: An increased midnight cortisol (MC) has been described in end-stage kidney disease (ESKD) and type 1 diabetes (T1D). Lower circulating levels of the cytokine soluble tumor necrosis factor (TNF)-like weak inducer of apoptosis (sTWEAK) have been found in T1D and ESKD and associated with cardiovascular (CV) events in the latter. We aimed to study MC and sTWEAK in simultaneous pancreas-kidney transplant (SPKT) recipients, and the association of these markers with CV risk factors and transplant outcomes.
View Article and Find Full Text PDFChanges in physical activity habits in subjects with type 1 diabetes: A comparative study 10 years apart.
Endocrinol Diabetes Nutr (Engl Ed)
May 2023
Introduction: Physical activity (PA) is highly recommended in type 1 diabetes (T1D). Few studies have reported the amount of PA performed by individuals with T1D in their daily life, and there is no information about changes over time.
Material And Methods: Cross-sectional study in patients with T1D from a referral hospital recruited in two different periods: data from the Biobank registers from 2009 and data from patients attending visits at the hospital in 2019, on a consecutive basis.
Article Synopsis
- People with type 1 diabetes (T1D) have problems with certain types of fats in their blood, which may increase their risk of heart disease.
- A study looked at T1D patients who had no previous heart issues but were considered high-risk, finding that many had carotid plaques that could lead to heart problems.
- The study showed that certain blood fat levels, especially those related to HDL and LDL, could help identify who is at the highest risk for heart disease in T1D patients.
Introduction: Cardiovascular disease (CVD) is the leading cause of mortality in type 1 diabetes (T1D). However, there is a need for daily practice tools for identifying those more prone to suffer from these events. We aimed to assess the relationships between nuclear magnetic resonance (H NMR)-based lipidomic analysis and several CVD risk variables (including preclinical carotid atherosclerosis) in individuals with T1D at high risk.
View Article and Find Full Text PDFBackground And Aims: Although cardiovascular disease (CVD) remains the leading cause of mortality in type 1 diabetes (T1D), the use of cardioprotective drugs is scarce. We aimed to evaluate the impact of carotid ultrasonography (US) on the improvement in cardiovascular risk factors (CVRFs) in T1D.
Methods And Results: T1D patients without CVD meeting criteria for lipid treatment according to guidelines (age ≥ 40 years, nephropathy and/or ≥ 10 years of diabetes duration with ≥ 1 additional CVRFs) were included.
Article Synopsis
- The study investigates the effects of diabetic neuropathy (DN) on outcomes after pancreas transplantation (PT) in patients with type 1 diabetes and end-stage kidney disease, focusing on graft survival and cardiovascular disease (CVD).
- Researchers analyzed data from 187 individuals who underwent PT between 1999 and 2015, measuring vibration perception thresholds (VPTs) to assess DN before and after the procedure.
- Results showed that while VPTs improved after PT, higher pretransplant VPTs were linked to a greater risk of graft failure and CVD, highlighting the importance of DN assessments in predicting posttransplant outcomes.
Objective: To evaluate the concordance between the 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD (ESC/EASD-2019) and the Steno T1 Risk Engine (Steno-Risk) cardiovascular risk scales for individuals with type 1 diabetes (T1D) without cardiovascular disease (CVD) and to analyze the relationships of their use with identification of preclinical atherosclerosis.
Research Design And Methods: We consecutively selected patients with T1D, without CVD, age ≥40 years, with nephropathy, and/or with ≥10 years of T1D evolution with another risk factor. The presence of plaque at different carotid segments was determined by ultrasonography.
Aims: Evaluate the relationship between high and low exposure continuous glucose monitoring (CGM)-derived glucometrics and micro- and macrovascular complications in type 1 diabetes (T1D).
Methods: Cross-sectional study in T1D without cardiovascular disease (CVD) and with ≥ 1 of the following: ≥40 years, diabetic nephropathy, or ≥ 10 years of diabetes duration with CVD risk factors. Glucometrics were obtained over 14 consecutive days: glucose management indicator (GMI) and proportion of time < 54 (TBR < 54), <70, 70-180 (TIR), >180 (TAR).
Several organ allocation protocols give priority to wait-listed simultaneous kidney-pancreas (SPK) transplant recipients to mitigate the higher cardiovascular risk of patients with diabetes mellitus on dialysis. The available information regarding the impact of preemptive simultaneous kidney-pancreas transplantation on recipient and graft outcomes is nonetheless controversial. To help resolve this, we explored the influence of preemptive simultaneous kidney-pancreas transplants on patient and graft survival through a retrospective analysis of the OPTN/UNOS database, encompassing 9690 simultaneous transplant recipients between 2000 and 2017.
View Article and Find Full Text PDFArticle Synopsis
- Simultaneous pancreas-kidney transplantation (SPKT) helps people with diabetes and kidney disease live longer and better lives.
- To make this procedure better, doctors and patients worked together to understand and improve how patients experience the transplant process.
- They found ways to make things quicker and easier, like reducing hospital visits and speeding up the waiting list for transplants, which made patients feel better about their care.
Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.
View Article and Find Full Text PDFThe purpose of this study is to investigate potential associations between optical coherence tomography angiography (OCTA) parameters and diabetic kidney disease (DKD) categories in type 1 diabetes mellitus (T1DM) patients and controls. A complete ocular and systemic examination, including OCTA imaging tests and bloods, was performed. OCTA parameters included vessel density (VD), perfusion density (PD), foveal avascular zone area (FAZa), perimeter (FAZp) and circularity (FAZc) in the superficial vascular plexus, and DKD categories were defined according to glomerular filtration rate (GFR), albumin-creatinine ratio (ACR) and KDIGO prognosis risk classifications.
View Article and Find Full Text PDFAims: Information on the impact of insulin therapy before pancreas donation on pancreas outcomes is scarce. We aim to explore the influence of insulin therapy before donation on recipient and pancreas graft survival.
Methods: Registry study including 12,841 pancreas recipients from the OPTN/UNOS registry performed between 2000 and 2017.
Article Synopsis
- This study investigated the link between glycated haemoglobin (HbA1c) levels and retinal measurements in type 1 Diabetes Mellitus (DM) patients, using optical coherence tomography (OCT) and OCT angiography (OCTA).
- It included 478 type 1 DM patients and 115 controls, analyzing data for those without diabetic retinopathy (DM-no DR) and with diabetic retinopathy (DM-DR), while comparing their HbA1c levels over time.
- The findings indicated that higher HbA1c levels are related to specific OCTA and OCT changes, suggesting that these measurements could help identify patients at risk for worsening diabetic eye disease.
Aims: Evaluate the weight trajectories after pancreas transplantation (PT) and their relationships with pancreas graft outcomes in type 1 diabetes (T1D).
Methods: Retrospective cohort study. T1D individuals who underwent PT were recruited (T1D-PT; n = 194) and divided into three groups according to transplantation date: 1999-2004 (n = 57), 2005-2009 (n = 79), 2010-2015 (n = 58).
Article Synopsis
- The study explores the link between fatty acid intake and cardiovascular disease (CVD) risk in individuals with type 1 diabetes (T1D) by examining carotid plaques as an indicator of future CVD events.
- The research included 167 T1D patients without CVD and found that certain fatty acids, particularly linoleic acid and all-C18:1trans, were significantly related to the presence of carotid plaques.
- The findings suggest that an unfavorable fatty acid intake pattern may increase CVD risk in T1D patients, highlighting the importance of dietary choices for this high-risk group.
Article Synopsis
- Glycoproteins are crucial in inflammation and cardiometabolic processes, and their role in atherosclerosis for type 1 diabetes (T1D) is being investigated.
- A study of 189 T1D patients (averaging 47 years old) found that while traditional inflammation markers like C-reactive protein didn't correlate with atherosclerosis, certain H-NMR glycoproteins (GlycA, GlycF) showed strong associations with carotid plaques, particularly in patients not on statins.
- The findings suggest that H-NMR glycoproteins could serve as potential biomarkers for cardiovascular disease in T1D patients, necessitating further research to confirm their value.
Background: Cardiovascular disease is the major cause of death in patients with type 1 diabetes. Of the available risk predictors for this population, the Steno Type 1 Risk Engine (STENO T1) is the only one that includes kidney function as a risk factor, which is a well-described independent risk factor for cardiovascular disease.
Methods: We explore how simultaneous pancreas-kidney transplantation (SPKT) modifies the predicted cardiovascular risk by the STENO T1 through a retrospective study including recipients of a first SPKT between 2000 and 2016.
Enteric complications remain a major cause of morbidity in the post-transplant period of pancreas transplantation despite improvements surgical technique. The aim of this single-center study was to analyze retrospectively the early intestinal complications and their potential relation with vascular events. From 2000 to 2016, 337 pancreas transplants were performed with systemic venous drainage.
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