Publications by authors named "Esmat Samiei"
Article Synopsis
- Blood-based small molecule metabolites can provide valuable insights into health and disease risk, especially in understanding heart failure (HF) through metabolite profiling in individuals who initially do not have HF.
- The study used network analysis to reveal how metabolites interact and their roles in influencing HF risk, while controlling for confounding factors among metabolites.
- Key findings indicate that certain metabolites, like glycine and asparagine, are linked to both dietary intake and genetic factors, highlighting their importance in predicting HF incidence and understanding complex health conditions.
Article Synopsis
- Monoclonal antibody therapies have improved cancer survival rates, but individual responses vary, necessitating the identification of cancer subtypes and biomarkers for effective treatment.*
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- This study focused on colorectal cancer, combining genotype and RNA-seq data to find biomarkers linked to overall survival for patients treated with cetuximab or bevacizumab.*
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- Notably, a gene found to be overexpressed in certain subtypes was linked to shorter survival for cetuximab patients, suggesting that specific subtypes may respond better to certain treatments.*
Article Synopsis
- This study focused on identifying gene interconnectivity, specifically in metastatic colorectal cancer (CRC), to improve patient treatment by linking gene networks to overall survival (OS) outcomes.
- Researchers analyzed data from 1,165 patients in a clinical trial comparing treatments with cetuximab and bevacizumab, discovering gene signatures that predict patient survival based on specific treatments.
- The identified gene signatures not only showed downregulation in CRC tumors compared to normal tissue but also highlighted proteins that interact functionally, indicating their potential as novel biomarkers for personalized cancer treatment.
