Publications by authors named "Esmaeil Samizadeh"
Background: Optimal selection of anastomosis technique is crucial in colectomy surgeries to ensure success and minimize postoperative complications. Various methods, both manual and stapler-assisted, are employed for intestinal anastomosis. This study aims to compare two surgical methods of intestinal anastomosis through macroscopic and microscopic examination.
View Article and Find Full Text PDFBackground: Prostate cancer is the second most common cancer in men. Central nervous system (CNS) involvement in prostate cancer which manifests as cerebral, leptomeningeal, or dural involvement is uncommon and occurs late in the course of disease.
Case: A 60-year-old patient with castration resistant prostate cancer (CRPC) presented with headache and fatigue.
Introduction: Immunohistochemistry (IHC) is crucial for breast cancer diagnosis, classification, and individualized treatment. IHC is used to measure the levels of expression of hormone receptors (estrogen and progesterone receptors), human epidermal growth factor receptor 2 (HER2), and other biomarkers, which are used to make treatment decisions and predict how well a patient will do. The evaluation of the breast cancer score on IHC slides, taking into account structural and morphological features as well as a scarcity of relevant data, is one of the most important issues in the IHC debate.
View Article and Find Full Text PDFβ-D-mannuronic Acid (M2000) and Inflammatory Cytokines in COVID-19; An In vitro Study.
Iran J Allergy Asthma Immunol
December 2022
Article Synopsis
- COVID-19 can lead to severe complications like ARDS, often linked to a cytokine storm and multiorgan failure, with treatment options including corticosteroids and NSAIDs.
- Researchers tested a new NSAID, mannuronic acid (M2000), for its potential to reduce inflammation in COVID-19 patients with ARDS, using blood samples in an in vitro study.
- The results showed that M2000 significantly lowered levels of key inflammatory markers (IL-6, IL-17, TNF-α, IFN-γ) in patient cells, suggesting it could be a promising treatment for managing severe COVID-19 inflammation.
The effect of Nigella sativa oil on vascular dysfunction assessed by flow-mediated dilation and vascular-related biomarkers in subject with cardiovascular disease risk factors: A randomized controlled trial.
Phytother Res
May 2022
Cardiovascular diseases (CVD) are the leading causes of mortality worldwide. Flow-mediated dilation (FMD) is a marker of vascular function. Beneficial cardiometabolic effects of Nigella sativa (N.
View Article and Find Full Text PDFTaraxacum syriacum (TS) with natural antioxidant and pharmacological activities may be considered for treatment of oxidative stress induced by acetaminophen (APAP). The aim of this study was to evaluate the ameliorative effects of the ethanol extract of TS root against hepatorenal toxicity induced by APAP in comparison to N-acetylcysteine (NAC) as a standard drug. Thirty male Wistar rats were randomly divided into five groups.
View Article and Find Full Text PDFBackground: Chronic inflammation is associated with neoplasms and several types of cancer. Therefore, polymorphisms in the inflammation-related genes could modify the cancer susceptibility.
Objective: To investigate the associations between IL-1RN VNTR and rs419598 polymorphisms in IL-1 receptor antagonist (IL-1ra) and colorectal cancer (CRC) and gastric cancer (GC) in an Iranian population.
Backgrounda: Aberrant activation of phosphatidylinositol-3 kinases (PI3K)/AKT/mTOR (mammalian target of rapamycin) pathway is a critical event during gastric cancer progression. Selective function of AKT inhibitor AZD5363 in PI3KCA mutant gastric cancer necessitates the assessment of PI3KCA mutations in these patients.
Methods: The study included 100 patients with gastric cancer who underwent surgical resection at Imam Reza Hospital, Tehran, Iran, between January 2009 and December 2016.
Background: There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis.
Objective: The aim of this study was to evaluate the addiction effects of morphine and its derivatives on rats spermatogenesis.
Materials And Methods: 40 male Wistar rats were randomly divided into 5 equal groups, which were exposed either with intravenous morphine, naloxone, naloxone and morphine, sham (with normal saline injection) and a control group without infusion.
Background: Andropause is a middle-age condition in which men experience changes in their physical, spiritual and emotional health. The association between andropause and psychological symptoms such as depression are not very clear yet.
Aims: The objective of this study was therefore to determine the association between the 'Aging Males Symptoms Scale' (AMS) and depression.