Synthesis of Novel Imine Stilbene Analogs Exhibiting Potent Anticancer Activity.

Background: Resveratrol (RV) and its analogues Aza-stilbenes were found effective in exhibiting anticancer activity.

Objective: The present study mainly focused on the green synthesis of novel imine stilbene analogues and evaluation of their anticancer activity besides their influence on hypoxia-induced gene expression in cancer cells.

Method: Novel imine stilbenes, differing in number and/or position of hydroxyl and methoxy functional groups, have been synthesized using green chemistry mediated condensation reaction between aldehydes and amines in the ethanolic extract of Psoralea corylifolia hairy roots and tested for their anticancer potential.