Publications by authors named "Esin Koc"

Article Synopsis
  • * The chances of survival for infants in this periviable stage vary greatly; earlier weeks see low survival rates and higher chances of complications, while later weeks show improved outcomes with proper medical care.
  • * National and international guidelines significantly influence the type of care provided to periviable infants, leading to varying practices across countries and ethical challenges for healthcare providers in determining the best approach for survival versus risk management.
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Introduction: The aim of the study was to analyse the clinical and demographic features of infants with gestational age (GA) of 32-37 weeks and birth weight (BW) of >1,500 g who developed treatment requiring retinopathy of prematurity (ROP).

Methods: Data on the infants with a GA of 32-37 weeks and BW >1,500 g who developed treatment requiring ROP (TR-ROP) were collected retrospectively from the 33 ROP centres in Turkiye. GA, BW, type of hospital, neonatal intensive care units (NICUs) level, presence of an ophthalmologist and neonatologist in the same hospital, length of stay in NICU, duration of oxygen therapy, comorbidities, type of ROP, and timing for TR-ROP development were analysed.

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Introduction: Laryngeal mask airway (LMA) use in neonatal resuscitation is limited despite existing evidence and recommendations. This survey investigated the knowledge and experience of healthcare providers on the use of the LMA and explored barriers and solutions for implementation.

Methods: This online, cross-sectional survey on LMA in neonatal resuscitation involved healthcare professionals of the Union of European Neonatal and Perinatal Societies (UENPS).

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(1) Background: Our survey aimed to gather information on respiratory care in Neonatal Intensive Care Units (NICUs) in the European and Mediterranean region. (2) Methods: Cross-sectional electronic survey. An 89-item questionnaire focusing on the current modes, devices, and strategies employed in neonatal units in the domain of respiratory care was sent to directors/heads of 528 NICUs.

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Article Synopsis
  • The study explored the occurrence and causes of neonatal meningitis across multiple centers in the country, focusing on the risk factors, complications, and outcomes of affected newborns.
  • Out of 634 cases analyzed, the incidence was found to be 2.51 per 1000 ICU admissions, with a notable mortality rate of 23.5%, primarily caused by Gram-positive bacteria, especially coagulase-negative Staphylococci.
  • Key risk factors for increased mortality included respiratory distress requiring ventilatory support, low birth weight, and lack of antenatal steroid exposure, highlighting severe clinical conditions associated with poor outcomes.
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Background: Researchers have attempted to automate the spontaneous movement assessment and have sought quantitative and objective methods over the past decade. The purpose of the study was to present a quantitative assessment method of spontaneous movement using center-of-pressure (COP) movement analysis.

Methods: A total of 101 infants were included in the study.

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Article Synopsis
  • - The study investigates the incidence of hypoxic ischemic encephalopathy (HIE) in infants ≥36 weeks gestational age in Turkey, finding an incidence rate of 2.13 per 1000 live births, with varying severity levels among those affected.
  • - Among infants with HIE, therapeutic hypothermia (TH) was notably administered to 34.5% of those with mild HIE, while factors like gestational age affected mortality rates, especially in those born at 34-35 weeks.
  • - Despite an unchanged incidence of HIE, the study revealed a decreased mortality rate and no significant impact of TH timing on MRI findings or mortality.
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Article Synopsis
  • Autosomal recessive congenital ichthyosis (ARCI) is a group of skin disorders that lead to the condition known as collodion baby at birth, with subtypes including Harlequin ichthyosis, lamellar ichthyosis, and others.
  • A male newborn was diagnosed with non-bullous congenital ichthyosiform erythroderma (NBCIE) and had whole exome sequencing which identified two specific gene variants in a compound heterozygous state.
  • This case is notable because it presents the first instance of two genetic variants associated with NBCIE, diverging from the previously reported cases linked to bathing suit ichthyosis (BSI).
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The objective was to apply a population model to describe the time course and variability of serum creatinine (sCr) in (near)term neonates with moderate to severe encephalopathy during and after therapeutic hypothermia (TH). The data consisted of sCr observations up to 10 days of postnatal age in neonates who underwent TH during the first 3 days after birth. Available covariates were birth weight (BWT), gestational age (GA), survival, and acute kidney injury (AKI).

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Background: Hyperbilirubinemia is a clinical picture frequently occurring in the neonatal period and may negatively affect the development of infants.

Aims: To evaluate term infants with hyperbilirubinemia in terms of both motor development and sensory processing skills and to compare them with their healthy peers without hyperbilirubinemia.

Study Design: A cross-sectional study.

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The aim of the present study, endorsed by the Union of European Neonatal and Perinatal Societies (UENPS) and the Italian Society of Neonatology (SIN), was to analyze the current delivery room (DR) stabilization practices in a large sample of European birth centers that care for preterm infants with gestational age (GA) < 33 weeks. Cross-sectional electronic survey was used in this study. A questionnaire focusing on the current DR practices for infants < 33 weeks' GA, divided in 6 neonatal resuscitation domains, was individually sent to the directors of European neonatal facilities, made available as a web-based link.

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Objective: Optimal care in the delivery room is important to decrease neonatal morbidity and mortality. We aimed to evaluate neonatal resuscitation practices in Turkish centers.

Materials And Methods: A cross-sectional survey consisted of a 91-item questionnaire focused on delivery room practices in neonatal resuscitation and was sent to 50 Turkish centers.

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of recommendationsCorticosteroids should be administered to women at a gestational age between 24 and 33weeks, when preterm birth is anticipated in the next seven days, as these have been consistently shown to reduce neonatal mortality and morbidity. (Strong-quality evidence; strong recommendation). In selected cases, extension of this period up to 34weeks may be considered (Expert opinion).

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Polycystic ovary syndrome (PCOS) is a common, complex endocrine, and metabolic disorder. Inflammation has been thought to play an important role in PCOS pathogenesis in recent years, and various inflammatory markers have been investigated; however, no definite conclusion has been reached. As a multifunctional regulatory protein in different inflammatory processes, calprotectin may play a role in the etiology of PCOS.

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Article Synopsis
  • The study investigates serum levels of kynurenine (KYN) and its metabolites in pregnant women with idiopathic fetal growth restriction (FGR) and oligohydramnios, as KYN is linked to important bodily functions like energy production and immune regulation.
  • Conducted as a case-control study at Ankara City Hospital, it compared pregnant women with FGR and oligohydramnios to low-risk controls, analyzing factors like age, BMI, and serum KYN levels.
  • Results showed significantly lower serum KYN levels in women with FGR and oligohydramnios, especially in those with FGR, indicating that KYN might be crucial in understanding and responding to these pregnancy complications.
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Objectives: In this article, we aimed to evaluate the most recent information on the impact of the COVID-19 pandemic on the health of mothers and their babies.

Methods: We conducted a literature search by utilizing online sources. Scientific papers that were written in English on the effects of COVID-19 on both mother and their newborn were assessed.

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Objective: Many methods are used in the treatment of coronavirus disease 2019 (COVID-19), which causes acute respiratory distress syndrome (ARDS), and there are conflicting reports in the literature regarding the results of mesenchymal stem cell (MSC) therapy, which is one of those methods. The aim of our study is to evaluate the effect of MSC treatment applied together with standard treatments on survival.

Materials And Methods: This retrospective case-control study evaluates the survival effect of MSC treatment administered to patients treated in intensive care after the development of ARDS due to COVID-19 between March 2020 and March 2021.

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Article Synopsis
  • There is a significant difference in kidney function and injury among neonates with neonatal encephalopathy treated with therapeutic hypothermia, suggesting that traditional definitions of acute kidney injury may miss critical patient-specific information.
  • A study analyzed data from 1,136 neonates undergoing therapeutic hypothermia, revealing an 11.6% incidence of acute kidney injury and a 17% mortality rate, with kidney function metrics being notably higher in those who did not survive.
  • By examining serum creatinine patterns in relation to postnatal age, clinicians can gain better insights into individual kidney functions, leading to more personalized care strategies for these vulnerable patients.
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Hypoxic-ischemic encephalopathy (HIE) is one of the substantial causes of developmental-cognitive disability in neonates. In this early period, it is difficult to diagnose accompanying or predisposing genetic diseases in HIE patients. Herein, we present a patient with HIE who was diagnosed with Pitt-Hopkins syndrome in the newborn period.

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Introduction: Intravenous immunoglobulin (IVIG) has been widely used to treat the hemolytic disease of the newborn (HDN). Although it has been shown that IVIG treatment reduces the duration of phototherapy and hospitalization, the use of IVIG in hemolytic disease due to ABO incompatibility has been controversial in recent years. This study aimed to investigate the role of IVIG in the prevention of exchange transfusion in infants with ABO HDN who presented with bilirubin levels at or above the level of exchange transfusion.

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Intimate partner violence (IPV) is an important problem that has significant detrimental effects on the wellbeing of female victims. The chronic physical and psychological effects of intimate partner violence (IPV) are complex, long-lasting, chronic, and require treatments focusing on improving mental health issues, safety, and support. Various psycho-social intervention programs are being implemented to improve survivor wellbeing.

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Objectives: To evaluate the impact of the presence and severity of urinary incontinence (UI) on pregnancy-related anxiety.

Study Design: This prospective case-control study included 160 pregnant women. Pregnant women with UI (n = 80) were compared with continent pregnant women (n = 80; control group) in terms of scores on the Incontinence Consultation Questionnaire-Short Form (ICIQ-SF) and the Pregnancy-related Anxiety Questionnaire-Revised 2 (PRAQ-R2) scale.

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