Distinct TP53 Mutation Subtypes Differentially Influence Cellular Iron Metabolism.

The most commonly mutated gene in all human cancers is the tumor suppressor gene ; however, in addition to the loss of tumor suppressor functions, mutations in can also promote cancer progression by altering cellular iron acquisition and metabolism. The primary objective of this work was to determine how mutation status influences the molecular control of iron homeostasis. The effect of mutation type on cellular iron homeostasis was examined using cell lines with inducible versions of either wild-type or a representative mutated gene from exemplary "hotspot" mutations in the DNA binding domain (R248, R273, and R175) as well as H193Y.

Effects of Game Pitch Count and Body Mass Index on Pitching Biomechanics in 9- to 10-Year-Old Baseball Athletes.

Background: Pitching while fatigued and body composition may increase the injury risk in youth and adult pitchers. However, the relationships between game pitch count, biomechanics, and body composition have not been reported for a study group restricted to 9- to 10-year-old athletes.

Hypothesis: During a simulated game with 9- to 10-year-old athletes, (1) participants will experience biomechanical signs of fatigue, and (2) shoulder and elbow kinetics will correlate with body mass index (BMI).

Cardiorespiratory Fitness and Reclassification of Risk for Incidence of Heart Failure: The Veterans Exercise Testing Study.

Background: It is well established that cardiorespiratory fitness (CRF) is inversely associated with cardiovascular and all-cause mortality. However, little is known regarding the association between CRF and incidence of heart failure (HF).

Methods And Results: Between 1987 and 2014, we assessed CRF in 21 080 HF-free subjects (58.