Publications by authors named "Esha V Rajadhyaksha"
Article Synopsis
- Three-dimensional (3D) culturing techniques mimic the structure of multicellular epithelial tissues, enabling researchers to study tissue development, drug testing, and tissue engineering for regenerative medicine.
- The study involved creating 3D epithelial tissues from foreskin, cervix, and tonsil cells, confirming their correct stratified structure using specific epithelial markers.
- RNA sequencing revealed unique gene expression patterns across these tissues, highlighting their different functions such as immune responses in tonsils and lipid metabolism in foreskin, providing valuable insights and a resource for further research.
Three-dimensional (3D) culturing techniques can recapitulate the stratified nature of multicellular epithelial tissues. Organotypic 3D epithelial tissue culture methods have several applications, including the study of tissue development and function, drug discovery and toxicity testing, host-pathogen interactions, and the development of tissue-engineered constructs for use in regenerative medicine. We grew 3D organotypic epithelial tissues from foreskin, cervix, and tonsil-derived primary cells and characterized the transcriptome of these tissue equivalents.
View Article and Find Full Text PDFPapillomaviruses have been evolving alongside their hosts for at least 450 million years. This review will discuss some of the insights gained into the evolution of this diverse family of viruses. Papillomavirus evolution is constrained by pervasive purifying selection to maximize viral fitness.
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