Publications by authors named "Esha Kadam"
Self-Reported Delayed Adverse Events and Flare Following COVID-19 Vaccination Among Patients With Autoimmune Rheumatic Disease (AIRD) in Malaysia: Results From the COVAD-2 Study.
Int J Rheum Dis
January 2025
Objectives: To determine the prevalence of self-reported delayed adverse events (DAEs), major AEs, and flares following COVID-19 vaccinations among patients with autoimmune rheumatic diseases (AIRDs) in Malaysia.
Methodology: An electronically validated survey from the COVID-19 vaccination in autoimmune diseases (COVAD) study group was distributed in July 2021 to patients with autoimmune diseases and healthy controls (HCs). The survey collected data on DAEs (any AE that persisted or occurred after 7 days of vaccination), any early or delayed major adverse events (MAEs), and flares following COVID-19 vaccination.
Article Synopsis
- This study explored the adverse events (AEs) related to COVID-19 vaccination in patients with rheumatoid arthritis (RA) as part of the COVAD-2 study, which surveyed participants from February to June 2022.
- It included 7203 participants, including 1423 RA patients, and found that RA patients reported higher rates of both major and minor AEs compared to healthy controls, and even more when compared to those with other autoimmune diseases.
- Active RA significantly increased the risk of major AEs and hospitalization, while patients on certain medications like methotrexate or TNF inhibitors experienced fewer AEs than those not on these treatments.
Article Synopsis
- The study investigates how comorbidities impact the quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared to other autoimmune diseases and healthy individuals, utilizing self-reported data from the COVAD-2 survey.
- Results show IIM patients have significantly higher rates of comorbidities, basic multitasking, complex multitasking, and mental health disorders.
- The presence of these conditions correlates with lower overall physical and mental health scores, suggesting the need for targeted management strategies for IIM patients based on identified clinical clusters.
Background Prevalence-based, non-comparative studies have been done to assess psychological and physical consequences of social media and gaming addiction. However, similar studies are lacking for binge-watching, especially in India. We compared the physical and psychological health impact between screen addicted and healthy screen users, by minimizing bias due to confounding factors.
View Article and Find Full Text PDFSpondyloarthritis (SpA) is a group of inflammatory disorders, including axial SpA (axSpA), characterized by inflammation in the spine and sacroiliac joints. Healthcare professionals have a crucial role in diagnosing and managing axSpA. Assessing their knowledge, perceptions, and practices is essential to enhance patient care.
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- A study investigated rare cases of systemic autoimmune diseases (SAIDs) reported after COVID-19 vaccinations by surveying individuals with new-onset SAIDs post-vaccination using a validated e-survey dataset.* -
- Of 16,750 participants, 74 reported new-onset SAIDs, mostly idiopathic inflammatory myopathies, arthritis, and polymyalgia rheumatica; higher incidences were found among Caucasians and Moderna vaccine recipients.* -
- The research concluded that while the occurrence of new-onset SAIDs post-vaccination is low, certain risk factors like pre-existing autoimmune diseases, mental health issues, and ethnicity were linked to these cases.*
Background: The pandemic presented unique challenges for individuals with autoimmune and rheumatic diseases (AIRDs) due to their underlying condition, the effects of immunosuppressive treatments, and increased vaccine hesitancy.
Objectives: The COVID-19 vaccination in autoimmune diseases (COVAD) study, a series of ongoing, patient self-reported surveys were conceived with the vision of being a unique tool to gather patient perspectives on AIRDs. It involved a multinational, multicenter collaborative effort amidst a global lockdown.
Article Synopsis
- The focus on holistic patient care for autoimmune and rheumatic diseases (AIRDs) emphasizes the importance of subjective well-being, social factors, and mental health, alongside traditional measures of disease.
- The COVAD-3 survey is set up as an extensive online self-report study to assess various lifestyle factors of AIRD patients and healthy individuals, ensuring it's accessible through multiple languages and thorough testing.
- The goal of COVAD-3 is to understand how social, economic, and psychological factors affect the quality of life in AIRD patients, ultimately aiming to enhance their overall health and treatment approaches.
Objectives: To investigate health-related quality of life in patients with idiopathic inflammatory myopathies (IIMs) compared with those with non-IIM autoimmune rheumatic diseases (AIRDs), non-rheumatic autoimmune diseases (nrAIDs) and without autoimmune diseases (controls) using Patient-Reported Outcome Measurement Information System (PROMIS) instrument data obtained from the second COVID-19 vaccination in autoimmune disease (COVAD-2) e-survey database.
Methods: Demographics, diagnosis, comorbidities, disease activity, treatments and PROMIS instrument data were analysed. Primary outcomes were PROMIS Global Physical Health (GPH) and Global Mental Health (GMH) scores.
Article Synopsis
- COVID-19 could trigger disease flares in rheumatoid arthritis (RA) patients, but the specific associated factors were unknown prior to this study.
- The study analyzed data from 1928 RA patients involved in the COVAD research, focusing on demographics, comorbidities, treatments, and disease flare details.
- Key findings indicate that younger age, non-Asian ethnicity, comorbidities, and certain treatments like methotrexate, along with aspects of physical and mental health, are important factors linked to disease flares in RA patients post-COVID-19.
Article Synopsis
- The study investigates delayed adverse events (DAEs) from COVID-19 vaccinations in patients with systemic lupus erythematosus (SLE) compared to other autoimmune diseases and healthy individuals, with a focus on data scarcity impacting vaccine hesitancy among immunocompromised individuals.
- The research, conducted through a global online survey of over 7200 individuals, found that SLE patients experienced significantly more major DAEs and hospitalizations post-vaccination than healthy controls and had higher rates of severe rashes compared to those with other rheumatic diseases.
- The findings suggest a need for careful monitoring of SLE patients post-vaccination due to their elevated risk of adverse events, particularly after receiving the Moderna vaccine.
To investigate the frequency, profile, and severity of COVID-19 breakthrough infections (BI) in patients with type I diabetes mellitus (T1DM) compared to healthy controls (HC) after vaccination. The second COVID-19 Vaccination in Autoimmune Diseases (COVAD-2) survey is a multinational cross-sectional electronic survey which has collected data on patients suffering from various autoimmune diseases including T1DM. We performed a subgroup analysis on this cohort to investigate COVID-19 BI characteristics in patients with T1DM.
View Article and Find Full Text PDFData on short-term safety of COVID-19 vaccination in patients with systemic sclerosis (SSc) were explored previously in the first COVID-19 vaccination in autoimmune diseases (COVAD) survey conducted in 2021. However, delayed adverse events (ADEs) (occurring > 7 days post-vaccination) are poorly characterized in these patients with SSc. In this study, we analysed delayed COVID-19 vaccine-related ADEs among patients with SSc, other systemic autoimmune and inflammatory disorders (SAIDs) and healthy controls (HCs) using data from the second COVAD study conducted in 2022.
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