Insights into Peptidyl-Prolyl - Isomerases from Clinically Important Protozoans: From Structure to Potential Biotechnological Applications.

Peptidyl-prolyl / isomerases (PPIases) are present in a wide variety of microorganisms, including protozoan parasites such as , , , , , , , , , , and , all of which cause important neglected diseases. PPIases are classified as cyclophilins, FKBPs, or parvulins and play crucial roles in catalyzing the isomerization of the peptide bond preceding a proline residue. This activity assists in correct protein folding.