Structural Basis for Alternative Self-Assembly Pathways Leading to Different Human Immunodeficiency Virus Capsid-Like Nanoparticles.

The mechanisms that underlie the spontaneous and faithful assembly of virus particles are guiding the design of self-assembling protein-based nanostructures for biomedical or nanotechnological uses. In this study, the human immunodeficiency virus (HIV-1) capsid was used as a model to investigate what molecular feature(s) may determine whether a protein nanoparticle with the intended architecture, instead of an aberrant particle, will be self-assembled . Attempts of using the HIV-1 capsid protein CA for achieving the self-assembly of cone-shaped nanoparticles that contain CA hexamers and pentamers, similar to authentic viral capsids, had typically yielded hexamer-only tubular particles.

Consistencies in Follow-up After Radical Cystectomy for Bladder Cancer: A Framework Based on Expert Practices Collaboratively Developed by the European Association of Urology Bladder Cancer Guideline Panels.

Background And Objective: There is no standardized regimen for follow-up after radical cystectomy (RC) for bladder cancer (BC). To address this gap, we conducted a multicenter study involving urologist members from the European Association of Urology (EAU) bladder cancer guideline panels. Our objective was to identify consistent post-RC follow-up strategies and develop a practice-based framework based on expert opinion.

The dopant (n- and p-type)-, band gap-, size- and stress-dependent field electron emission of silicon nanowires.

This study investigates the electron field emission (EFE) of vertical silicon nanowires (Si NWs) fabricated on n-type Si (100) and p-type Si (100) substrates using catalyst-induced etching (CIE). The impact of dopant types (n- and p-types), optical energy gap, crystallite size and stress on EFE parameters has been explored in detail. The surface morphology of grown SiNWs has been characterized by field emission scanning electron microscopy (FESEM), showing vertical, well aligned SiNWs.

Symmetry Breaking-Induced Resonance Dynamics in Bloch Point Nanospheres: Unveiling Magnetic Volume Effects and Geometric Parameters for Advanced Applications in Magnetic Sensing and Spintronics.

This study explores the impact of symmetry breaking on the ferromagnetic resonance of Bloch point (BP) nanospheres. Through standard Fourier analysis, we unveil two distinct oscillation mode groups characterized by low and high frequencies, respectively. Our findings emphasize the pivotal role of magnetic volume in shaping resonance amplitudes, providing new insights into the intricate dynamics of BP states.

Static and dynamic magnetic properties of circular and square cobalt nanodots in hexagonal cells.

In this work we performed a detailed numerical analysis to investigate the static and dynamic magnetic properties of hexagonal cells of square and circular cobalt nanodots as a function of the distance between them and the external magnetic field to which they are subjected. By simulating hysteresis curves with the external magnetic field applied parallel and perpendicular to the plane of these nanostructures, we can conclude that the cobalt nanodots presented a significant perpendicular magnetic anisotropy. We also obtained that the coercivity increases with decreasing volume, which implies that the circular dots have a higher coercivity than the square dots.

Antigiardial and antiamebic activities of fexinidazole and its metabolites: new drug leads for giardiasis and amebiasis.

The intestinal parasites and are major causes of morbidity and mortality associated with diarrheal diseases. Metronidazole is the most common drug used to treat giardiasis and amebiasis. Despite its efficacy, treatment failures in giardiasis occur in up to 5%-40% of cases.

Tunable Magnetic Properties of Interconnected Permalloy Nanowire Networks.

In this study, we investigate the magnetic properties of interconnected permalloy nanowire networks using micromagnetic simulations. The effects of interconnectivity on the hysteresis curves, coercivity, and remanence of the nanowire networks are analyzed. Our results reveal intriguing characteristics of the hysteresis curves, including nonmonotonic behaviors of coercivity as a function of the position of horizontal nanowires relative to vertical nanowires.

Dynamic susceptibility of FeO nanotubes.

In this work we performed a detailed numerical analysis to investigate the dynamic susceptibility of 1000 nm long FeO nanotubes by varying the diameter, the tube wall thickness and the magnitude of the external magnetic field applied along the tube axis. We found two well-defined modes, one of low frequency associated with the caps of the nanotubes, and another of high frequency associated with the central area of the nanotubes, which can be controlled by varying the geometry of the tubes or the external magnetic field to which they are subjected. These results allow us to suggest the use of these nanotubes in applications that require controlling the resonant frequency in the GHz range.

Static and Dynamic Magnetic Properties of FeO Nanotubes.

In this paper, our objective was to investigate the static and dynamic magnetic properties of FeO nanotubes that are 1000 nm long, by varying the external radius and the thickness of the tube wall. We performed a detailed numerical analysis by simulating hysteresis curves with an external magnetic field applied parallel to the axis of the tubes (along the -axis). Our findings indicate that nanotubes with an external radius of 30 nm exhibit non-monotonic behavior in their coercivity due to a change in the magnetization reversal mechanism, which was not observed in nanotubes with external radii of 80 nm.

Curvature-induced stabilization and field-driven dynamics of magnetic hopfions in toroidal nanorings.

Three dimensional magnetic textures are a cornerstone in magnetism research. In this work, we analyze the stabilization and dynamic response of a magnetic hopfion hosted in a toroidal nanoring with intrinsic Dzyaloshinskii-Moriya interaction simulating FeGe. Our results evidence that unlike their planar counterparts, where perpendicular magnetic anisotropies are necessary to stabilize hopfions, the shape anisotropy originated on the torus symmetry naturally yields the nucleation of these topological textures.

Hollow Iron Oxide Nanospheres Obtained through a Combination of Atomic Layer Deposition and Electrospraying Technologies.

In the present study, we report on the successful synthesis of hollow iron oxide nanospheres. The hollow FeO nanospheres were synthesized following a four-step procedure: electrospraying spherical PVP particles, coating these particles with alumina (AlO) and hematite (FeO) through atomic layer deposition and, finally, a thermal reduction process to degrade the polymer (PVP) and convert hematite (FeO) into magnetite (FeO). A structural analysis using X-ray diffraction (XRD) confirmed the effectiveness of the thermal reduction process.

Large-Area Nanopillar Arrays by Glancing Angle Deposition with Tailored Magnetic Properties.

Ferromagnetic films down to thicknesses of tens of nanometers and composed by polycrystalline Fe and FeO nanopillars are grown in large areas by glancing angle deposition with magnetron sputtering (MS-GLAD). The morphological features of these films strongly depend on the growth conditions. Vertical or tilted nanopillars have been fabricated depending on whether the substrate is kept rotating azimuthally during deposition or not, respectively.

CT Enterography for Preoperative Evaluation of Peritoneal Carcinomatosis Index in Advanced Ovarian Cancer.

To compare the diagnostic performance of routine CT (rCT), CT enterography (CTE) and intraoperative quantification of PCI to surgical and pathological reference standards in patients with advanced ovarian cancer, a retrospective study of 122 patients who underwent cytoreduction surgery for ovarian peritoneal carcinomatosis was conducted. Radiological, surgical, and pathological PCIs were obtained from the corresponding reports, and the latter two were considered reference standards. The radiological techniques used were rCT: 64 MDCT (32 × 1 mm) (100 mL iopromide 370 i.

Magnonic key based on skyrmion clusters.

In this work, we report the excitation of spin-waves modes in skyrmion clusters hosted in Co/Pt nanodots by applying an in-plane magnetic field pulse. The direction at which the magnetic field is applied enables the excitation of five main spin-waves modes that are understood in terms of only azimuthal-like modes, which are shown to be strongly dependent on the number of skyrmions stabilized in the system. This feature converts the present system in a mechanism to activate and suppress a set of given modes, which in turn we propose to be utilized as a magnonic key based skyrmion cluster.

SARS-CoV-2 Prevalence in Laparoscopic Surgery Filters. Analysis in Patients with Negative Oropharyngeal RT-qPCR in a Pandemic Context: A Cross-Sectional Study.

Objective: Surgical societies of different specialties have lately demonstrated a growing concern regarding the potential risk of SARS-CoV-2 transmission during surgery, mainly via aerosols carrying SARS-CoV-2 particles during laparoscopy smoke evacuation. Since there is not sufficient scientific evidence to rule out this hypothesis, our study aimed to evaluate the prevalence of the appearance of SARS-CoV-2 genetic material in the in-filter membrane of the smoke filter systems, used in laparoscopic surgery, in a tertiary referral hospital during the peak phases of the pandemic.

Methods: During the highest incidence of the pandemic outbreak, 180 laparoscopic smoke evacuation systems were collected from laparoscopies performed between April 2020 and May 2021 in University General Hospital of Castellón.

Information storage in permalloy modulated magnetic nanowires.

A long piece of magnetic material shaped as a central cylindrical wire (diameter [Formula: see text] nm) with two wider coaxial cylindrical portions (diameter [Formula: see text] nm and thickness [Formula: see text] nm) defines a bimodulated nanowire. Micromagnetism is invoked to study the equilibrium energy of the system under the variations of the positions of the modulations along the wire. The system can be thought of as composed of five independent elements (3 segments and 2 modulations) leading to [Formula: see text] possible different magnetic configurations, which will be later simplified to 4.

5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/β-catenin pathway in human uterine leiomyomas.

Background: Uterine leiomyoma is a benign tumor with unclear pathogenesis and inaccurate treatment. This tumor exhibits altered DNA methylation related to disease progression. DNMT inhibitors as 5-aza-2'-deoxycytidine (5-aza-CdR), have been suggested to treat tumors in which DNA methylation is altered.

Validation of three predictive models for suboptimal cytoreductive surgery in advanced ovarian cancer.

The standard treatment for advanced ovarian cancer (AOC) is cytoreduction surgery and adjuvant chemotherapy. Tumor volume after surgery is a major prognostic factor for these patients. The ability to perform complete cytoreduction depends on the extent of disease and the skills of the surgical team.

Postoperative Intestinal Fistula in Primary Advanced Ovarian Cancer Surgery.

Background: Advanced ovarian cancer (AOC) requires an aggressive surgery with large visceral resections in order to achieve an optimal or complete cytoreduction and increase the patient's survival. However, the surgical aggressiveness in the treatment of AOC is not exempt from major complications, such as the gastrointestinal fistula (GIF), which stands out among others due to its high morbidity and mortality.

Methods: We evaluated the clinicopathological features in patients with AOC and their association with GI.

Correction to: Outcome quality standards in advanced ovarian cancer surgery.

An amendment to this paper has been published and can be accessed via the original article.

Outcome quality standards in advanced ovarian cancer surgery.

Introduction: Advanced ovarian cancer surgery (AOCS) frequently results in serious postoperative complications. Because managing AOCS is difficult, some standards need to be established that allow surgeons to assess the quality of treatment provided and consider what aspects should improve. This study aimed to identify quality indicators (QIs) of clinical relevance and to establish their acceptable quality limits (i.

Dynamic and static properties of stadium-shaped antidot arrays.

In this work we performed a detailed numerical analysis on the static and dynamic properties of magnetic antidot arrays as a function of their geometry. In particular, we explored how by varying the shape of these antidot arrays from circular holes to stadium-shaped holes, we can effectively control the magnetic properties of the array. Using micromagnetic simulations we evidenced that coercivity is very sensitive to the shape of antidots, while the remanence is more robust to these changes.

The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival.

Objective: The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the results of the surgical technique of preoperative aortic lymphadenectomy in LACC related to tumor burden and disease spread to assess its influence on survival.

Methods: Data of 1,072 patients with cervical cancer were taken from 11 Spanish hospitals (Spain-Gynecologic Oncology Group [GOG] working group).

Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation.

Objective: To study whether vitamin D (VitD) inhibits cell proliferation and Wnt/β-catenin and transforming growth factor-β (TGFβ) signaling pathways in uterine leiomyomas independent of mediator complex subunit 12 (MED12) mutation status.

Design: Prospective study comparing leiomyoma vs. myometrial tissues and human uterine leiomyoma primary (HULP) cells treated with or without VitD and analyzed by MED12 mutation status.